{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T18:12:52Z","timestamp":1783620772148,"version":"3.55.0"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurosciences"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Synaptic plasticity markers are known to be altered in schizophrenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The objectives of the study were to analyse neurexin-3 levels and their relation with severity in schizophrenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 216 schizophrenia patients and 216 healthy volunteers were enrolled. Neurexin-3 was analysed by enzyme-linked immunosorbent assay. The severity of schizophrenia was determined using the Positive and Negative Syndrome Scale (PANSS) scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Neurexin-3 levels were significantly reduced (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .001) and positively associated with negative symptom score (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .037), general psychopathological score (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .025) and total PANSS score (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .019) in schizophrenia cases. Neurexin-3 was significantly increased (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .05), and disease duration (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .05) was significantly reduced in schizophrenia patients with marked illness compared to those with mild illness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We conclude that neurexin-3 is reduced and is associated with the severity of schizophrenia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09727531261452824","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:31:15Z","timestamp":1783427475000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Plasma Neurexin-3 with Severity of Schizophrenia"],"prefix":"10.1177","author":[{"given":"Neha","family":"Keshri","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7152-1143","authenticated-orcid":false,"given":"Hanumanthappa","family":"Nandeesha","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8035-4658","authenticated-orcid":false,"given":"Vikas","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxn001"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.3.247"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.1737"},{"key":"e_1_3_7_5_2","article-title":"Emerging synaptic molecules as candidates in the etiology of neurological disorders","volume":"1","author":"Torres VI","year":"2017","unstructured":"Torres VI, , Vallejo D, , and Inestrosa NC. 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