{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:45:49Z","timestamp":1785941149761,"version":"3.56.0"},"reference-count":26,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurosciences"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The adversities and inheritance patterns of left-handedness have been associated with gender-related distress. Such driving factors predispose individuals to multiple mental health outcomes, shifting attention to the role of ruminative thinking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The study seeks to examine the effects of handedness patterns on gender dysphoria and rumination among young adults, observing the intricate relationships among these variables and postulating a substantial influence of handedness on both gender-related distress and rumination in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional design with purposive sampling was used to recruit 180 young adults aged 18\u201325 years. Study parameters were quantified using three self-report measures: the Edinburgh Handedness Inventory\u2013Short Form, the Utrecht Gender Dysphoria Scale\u2013Gender Spectrum, and the Rumination\u2013Reflection Questionnaire. Data were analysed through moderation tests, correlation tests, and descriptive statistics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results reveal that the links between rumination and gender dysphoria appear to be stronger in left-handed than in right-handed participants. Furthermore, variations in rumination and handedness patterns in the sample contributed to a significant interaction effect (19.1%) in gender dysphoria, moderated by rumination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The study presents a comprehensive perspective for considering and structuring interventions for individuals with gender-related distress, covering major concepts of hormonal and genetic mechanisms, also underscoring the relevance of handedness and rumination in clinical and research settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09727531261459785","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T10:53:47Z","timestamp":1785754427000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cognitive and Affective Correlates of Handedness: Interactions with Gender Dysphoria and Rumination"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4809-7117","authenticated-orcid":false,"given":"Madhavan H.","family":"Varadarajan","sequence":"first","affiliation":[{"name":"Department of Applied Psychology, Faculty of Behavioural and Social Sciences, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3041-3648","authenticated-orcid":false,"given":"Durga Rangaswamy","family":"Pandian","sequence":"additional","affiliation":[{"name":"Department of Applied Psychology, Faculty of Behavioural and Social Sciences, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, India"},{"name":"Current affiliation: Psychology, School of Social Sciences and Languages, Vellore Institute of Technology, Chennai Campus, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1963-1603","authenticated-orcid":false,"given":"Jooshika","family":"D. K.","sequence":"additional","affiliation":[{"name":"Department of Applied Psychology, Faculty of Behavioural and Social Sciences, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8575-6183","authenticated-orcid":false,"given":"Darshini","family":"Madanagopal","sequence":"additional","affiliation":[{"name":"Department of Applied Psychology, Faculty of Behavioural and Social Sciences, Sri Ramachandra Institute of Higher Education and Research (DU), Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"e_1_3_9_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-7610.00773"},{"key":"e_1_3_9_3_2","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.104.4.714"},{"key":"e_1_3_9_4_2","unstructured":"Annett M. 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