{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:21:05Z","timestamp":1788459665103,"version":"build-2803163510"},"reference-count":24,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurosciences"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>COVID-19 has subacute as well as long-term effects defined as long COVID on multiple organ systems. Emerging literature suggests long-term effects of COVID-19 on the autonomic nervous system in survivors, the mechanistic basis of which is currently not delineated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The study aimed to assess the cardiovascular autonomic functions in mild COVID-19 survivors and compare them with age- and sex-matched healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited 34 young adult mild COVID-19 survivors. Autonomic function was assessed by cardiovascular autonomic reactivity tests at least 1 month after clinical recovery from acute COVID-19 infection. The responses were compared with those of 34 age- and sex-matched pre-COVID era healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mild COVID-19 survivors had significantly lower Valsalva ratio (1.578 \u00b1 0.2747 vs 1.773 \u00b1 0.3459;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .0156) and displayed a greater fall in systolic blood pressure during head-up tilt test (\u22129.206 \u00b1 7.121 vs 1.147 \u00b1 8.457;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; .0001) in comparison to the healthy controls. Haemodynamic cardiovascular autonomic abnormalities were seen in 47% of COVID-19 survivors. Haemodynamic criteria of orthostatic hypotension were met in 12% of COVID-19 survivors, and postural orthostatic tachycardia syndrome haemodynamic criteria were met in 35% of COVID-19 survivors. Autonomic reflex responses to deep breathing, handgrip test and cold pressor test were found to be comparable between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Young adult mild COVID-19 survivors show lower cardiovagal and cardiovascular adrenergic responses to baroreflex-dependent autonomic reactivity as medium- to long-term autonomic sequelae. They have an intact non-baroreflex-dependent autonomic reactivity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09727531261477282","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:36:11Z","timestamp":1788258971000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Baroreflex-dependent Cardiovascular Autonomic Reactivity is Deranged in Young Adult Mild COVID-19 Survivors"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1612-663X","authenticated-orcid":false,"given":"Ayan","family":"Roy","sequence":"first","affiliation":[{"name":"Department of Physiology, All India Institute of Medical Sciences, New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4331-4512","authenticated-orcid":false,"given":"Dinu S.","family":"Chandran","sequence":"additional","affiliation":[{"name":"Department of Physiology, All India Institute of Medical Sciences, New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1140-6976","authenticated-orcid":false,"given":"Ashok","family":"Jaryal","sequence":"additional","affiliation":[{"name":"Department of Physiology, All India Institute of Medical Sciences, New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8619-7929","authenticated-orcid":false,"given":"Manish","family":"Soneja","sequence":"additional","affiliation":[{"name":"Department of Medicine, All India Institute of Medical Sciences, New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6418-4388","authenticated-orcid":false,"given":"Ambuj","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Cardiology, All India Institute of Medical Sciences, New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0734-1097","authenticated-orcid":false,"given":"Kishore Kumar","family":"Deepak","sequence":"additional","affiliation":[{"name":"Centre for Biomedical Engineering, Indian Institute of Technology, New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_3_10_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20568-4"},{"key":"e_1_3_10_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m3026"},{"key":"e_1_3_10_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n136"},{"key":"e_1_3_10_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26552"},{"key":"e_1_3_10_6_2","doi-asserted-by":"publisher","DOI":"10.19102\/icrm.2020.111102"},{"key":"e_1_3_10_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2020.606779"},{"key":"e_1_3_10_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-021-00803-8"},{"key":"e_1_3_10_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.640835"},{"issue":"1","key":"e_1_3_10_10_2","first-page":"14","article-title":"Autonomic nervous system function","volume":"10","author":"Low PA.","year":"1993","unstructured":"Low PA. Autonomic nervous system function. J Clin Neurophysiol Off Publ Am Electroencephalogr Soc 1993; 10(1): 14\u201327. DOI: 10.1097\/00004691-199301000-00003. PMID: 8458992.","journal-title":"J Clin Neurophysiol Off Publ Am Electroencephalogr Soc"},{"key":"e_1_3_10_11_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.8.5.491"},{"key":"e_1_3_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2020.11.024"},{"key":"e_1_3_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2019.12.024"},{"key":"e_1_3_10_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-015-0294-x"},{"key":"e_1_3_10_15_2","doi-asserted-by":"publisher","DOI":"10.1139\/h05-018"},{"key":"e_1_3_10_16_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S382331"},{"key":"e_1_3_10_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20365"},{"key":"e_1_3_10_18_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP281888"},{"issue":"6","key":"e_1_3_10_19_2","first-page":"767","article-title":"Objective hemodynamic cardiovascular autonomic abnormalities in post-acute sequelae of COVID-19","volume":"39","author":"Hira R","year":"2023","unstructured":"Hira R, , Baker JR, , Siddiqui T, . Objective hemodynamic cardiovascular autonomic abnormalities in post-acute sequelae of COVID-19. Can J Cardiol 2023; 39(6): 767\u2013775. DOI: 10.1016\/j.cjca.2022.12.002. PMID: 36509178; PMCID: PMC9733966.","journal-title":"Can J Cardiol"},{"key":"e_1_3_10_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2022.103071"},{"key":"e_1_3_10_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.13776"},{"key":"e_1_3_10_22_2","first-page":"434","article-title":"How COVID-19 can cause autonomic dysfunctions and postural orthostatic syndrome? A review of mechanisms and evidence","author":"Hassani M","unstructured":"Hassani M, , Fathi Jouzdani A, , Motarjem S, . How COVID-19 can cause autonomic dysfunctions and postural orthostatic syndrome? A review of mechanisms and evidence. Neurol Clin Neurosci 2021; 9(6): 434\u2013442. 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