{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:44:23Z","timestamp":1791956663559,"version":"4.3.4"},"reference-count":44,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Annals of Neurosciences"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Antioxidants possess substantial health benefits owing to their ability to alleviate cellular oxidative stress, reactive oxygen species generation and inflammation. Vitamins, dietary fatty acids, minerals, micronutrients and plant-derived flavonoids have attracted significant attention for their primary role in maintaining brain health by attenuating oxidative stress and neuroinflammation, the key culprits in neurodegenerative pathologies and age-related cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Vitamin E is a fat-soluble antioxidant with isomers categorised as tocopherols and tocotrienols. Delta-tocotrienol (\u03b4-T3) is an isomer with an unsaturated isoprenoid side chain that confers better membrane penetration and enhanced bioactivities, including scavenging of free radicals, anti-inflammatory and cholesterol-lowering effects. However, the neurodifferentiation and neurocognitive potential of \u03b4-T3 and its bioactive conjugate \u03b4-T3\u2013\u03b3CD beyond its classical antioxidant properties is not known.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In the present study, using rodent-derived PC12 neuroblastoma and C6 glioblastoma cell lines, we assessed the\n                      <jats:bold>differentiation<\/jats:bold>\n                      potential of \u03b4-T3 and its unique complex with \u03b3Cyclodextrin (\u03b4-T3\u2013\u03b3CD). Further, an animal model of scopolamine (SC)-induced memory dysfunction was employed to evaluate the effect of \u03b4-T3 and \u03b4-T3\u2013\u03b3CD on memory processes and key molecular markers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Here, we report that brain-derived cells cultured in low, nontoxic doses of \u03b4-T3 exhibit differentiation. In the SC-induced amnesic mouse model, \u03b4-T3 reversed object recognition memory impairment, concomitantly increasing cortical and hippocampal neural progenitor and differentiation markers, mature neuron markers and neurotrophic factors. Of note, \u03b4-T3\u2013\u03b3CD (\u03b4-T3 complexed with \u03b3Cyclodextrin), containing only 20.7% \u03b4-T3, showed a stronger effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\u03b4-T3 showed neurodifferentiation and anti-amnesic potential with improved efficacy when complexed with \u03b3Cyclodextrin (\u03b4-T3\u2013\u03b3CD) in both cellular and mouse model systems. Cyclodextrin-enabled \u03b4-T3 might be a useful resource for the treatment of stress- and age-related memory dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09727531261479841","type":"journal-article","created":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T16:30:21Z","timestamp":1791736221000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cyclodextrin-enabled \u03b4-Tocotrienol for Treating Stress and Memory Dysfunction: Molecular Insights, Biotechnological Applications and Biomanufacturing Implications"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1761-1065","authenticated-orcid":false,"given":"Arpita","family":"Konar","sequence":"first","affiliation":[{"name":"Institute of Health Sciences, Presidency University, Kolkata, West Bengal, India"},{"name":"AIST-INDIA DAILAB, National Institute of Advanced Industrial Science &amp; Technology (AIST), Tsukuba, Ibaraki, Japan"},{"name":"CSIR-Institute of Genomics and Integrative Biology, New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanshu","family":"Bhargava","sequence":"additional","affiliation":[{"name":"AIST-INDIA DAILAB, National Institute of Advanced Industrial Science &amp; Technology (AIST), Tsukuba, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumi","family":"Hirano","sequence":"additional","affiliation":[{"name":"AIST-INDIA DAILAB, National Institute of Advanced Industrial Science &amp; Technology (AIST), Tsukuba, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Ishida","sequence":"additional","affiliation":[{"name":"CycloChem Bio Co., Ltd., Kobe, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Nakata","sequence":"additional","affiliation":[{"name":"CycloChem Bio Co., Ltd., Kobe, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Terao","sequence":"additional","affiliation":[{"name":"CycloChem Bio Co., Ltd., Kobe, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil C.","family":"Kaul","sequence":"additional","affiliation":[{"name":"AIST-INDIA DAILAB, National Institute of Advanced Industrial Science &amp; Technology (AIST), Tsukuba, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu","family":"Wadhwa","sequence":"additional","affiliation":[{"name":"AIST-INDIA DAILAB, National Institute of Advanced Industrial Science &amp; Technology (AIST), Tsukuba, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"key":"e_1_3_10_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8416763"},{"key":"e_1_3_10_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184472"},{"key":"e_1_3_10_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1389454"},{"key":"e_1_3_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.01.008"},{"key":"e_1_3_10_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.12964"},{"key":"e_1_3_10_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10121917"},{"key":"e_1_3_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2023.111855"},{"key":"e_1_3_10_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00030.2022"},{"key":"e_1_3_10_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.00041"},{"key":"e_1_3_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2025.118241"},{"key":"e_1_3_10_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.944697"},{"key":"e_1_3_10_13_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170732"},{"key":"e_1_3_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2011.05.008"},{"key":"e_1_3_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.12.032"},{"key":"e_1_3_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.07.067"},{"key":"e_1_3_10_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-025-04235-3"},{"key":"e_1_3_10_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30940"},{"key":"e_1_3_10_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells14070511"},{"key":"e_1_3_10_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.06.029"},{"key":"e_1_3_10_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2009.05.009"},{"key":"e_1_3_10_22_2","first-page":"195","article-title":"The neuroprotective effects of tocotrienol rich fraction and alpha tocopherol against glutamate injury in astrocytes","volume":"14","author":"Selvaraju TR","year":"2014","unstructured":"Selvaraju TR, , Khaza\u2019ai H, , Vidyadaran S, . 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