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In this study, in recombinant adenovirus-ASPP2-infected HepG2 cells, ASPP2 overexpression induces amphiregulin expression in a p53-dependent manner. Although amphiregulin initially contributes to ASPP2-induced apoptosis, it eventually impairs the pro-apoptotic function of ASPP2 by activating the epidermal growth factor\/epidermal growth factor receptor\/SOS1 pathway, leading to apoptosis resistance. Moreover, blocking soluble amphiregulin with a neutralizing antibody also significantly increased apoptotic cell death of HepG2 cells due to treatment with methyl methanesulfonate, cisplatin, or a recombinant p53 adenovirus, suggesting that the function of amphiregulin involved in inhibiting apoptosis may be a common mechanism by which hepatoma cells escape from stimulus-induced apoptosis. Thus, our data elucidate an apoptosis-evasion mechanism in hepatocellular carcinoma and have potential implications for hepatocellular carcinoma therapy.<\/jats:p>","DOI":"10.1177\/1010428317695026","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T02:55:16Z","timestamp":1490756116000},"page":"101042831769502","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Amphiregulin impairs apoptosis-stimulating protein 2 of p53 overexpression\u2013induced apoptosis in hepatoma cells"],"prefix":"10.1177","volume":"39","author":[{"given":"Kai","family":"Liu","sequence":"first","affiliation":[{"name":"Beijing Institute of Hepatology, Capital Medical University affiliated Beijing You An Hospital, Beijing, P.R. China"},{"name":"Capital Medical University affiliated Beijing You An Hospital, Beijing, P.R. 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