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Exact mechanism of action of salinomycin is not yet known, but there are multiple pathways by which salinomycin inhibits tumor growth. Salinomycin decreases the expression of adenosine triphosphate\u2013binding cassette transporter in multidrug resistance cells and interferes with Akt signaling pathway, Wnt\/\u03b2-catenin, Hedgehog, and Notch pathways of cancer progression. Salinomycin selectively targets cancer stem cells. 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