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In this study, we found that the long non-coding RNA colon cancer\u2013associated transcript 1 was upregulated in hepatocellular carcinoma tissues (p\u2009&lt;\u20090.05), and high colon cancer\u2013associated transcript 1 expression level was positively associated with tumor volume (p\u2009&lt;\u20090.05) and American Joint Committee on Cancer stage (p\u2009&lt;\u20090.05) in hepatocellular carcinoma patients. Luciferase reporter assays and RNA-pulldown assays showed that colon cancer\u2013associated transcript 1 is a target of miR-490-3p. Real-time quantitative polymerase chain reaction and Western blot analysis indicated that colon cancer\u2013associated transcript 1 regulated cyclin-dependent kinase 1 expression as a competing endogenous RNA by sponging miR-490-3p in hepatocellular carcinoma cells. Furthermore, colon cancer\u2013associated transcript 1 silencing decreased hepatocellular carcinoma cells proliferation and invasion and overexpression promoted cell proliferation and invasion in vitro. These data demonstrated that the colon cancer\u2013associated transcript 1\/miR-490-3p\/cyclin-dependent kinase 1 regulatory pathway promotes the progression of hepatocellular carcinoma. Inhibition of colon cancer\u2013associated transcript 1 expression may be a novel therapeutic strategy for hepatocellular carcinoma.<\/jats:p>","DOI":"10.1177\/1010428317697572","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T01:14:21Z","timestamp":1491441261000},"page":"101042831769757","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Long non-coding RNA colon cancer\u2013associated transcript 1 functions as a competing endogenous RNA to regulate cyclin-dependent kinase 1 expression by sponging miR-490-3p in hepatocellular carcinoma progression"],"prefix":"10.1177","volume":"39","author":[{"given":"Chunqing","family":"Dou","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chinese PLA General Hospital, Beijing, 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