{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:33:40Z","timestamp":1790681620180,"version":"4.1.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumour Biol."],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>Ovarian cancer is the most lethal gynecologic malignancy, due to its high propensity for metastasis. Cancer-associated fibroblasts, as the dominant component of tumor microenvironment, are crucial for tumor progression. However, the mechanisms underlying the regulation of ovarian cancer cells by cancer-associated fibroblasts remain little known. Here, we first isolated cancer-associated fibroblasts from patients\u2019 ovarian tissues and found that cancer-associated fibroblasts promoted SKOV3 cells\u2019 proliferation, migration, and invasion. Fibroblast growth factor-1 was identified as a highly increased factor in cancer-associated fibroblasts compared with normal fibroblasts by quantitative reverse transcription polymerase chain reaction (~4.6-fold, p\u2009&lt;\u20090.01) and ELISA assays (~4-fold, p\u2009&lt;\u20090.01). High expression of fibroblast growth factor-1 in cancer-associated fibroblasts either naturally or through gene recombination led to phosphorylation of fibroblast growth factor receptor 4 in SKOV3 cells, which is followed by the activation of mitogen-activated protein kinase\/extracellular signal\u2013regulated protein kinase pathway and epithelial-to-mesenchymal transition\u2013associated gene Snail1 and MMP3 expression. Moreover, treatment of SKOV3 cell with fibroblast growth factor receptor inhibitor PD173074 terminated cellular proliferation, migration, and invasion, reduced the phosphorylation level of fibroblast growth factor receptor 4, and suppressed the activation of mitogen-activated protein kinase\/extracellular signal\u2013regulated protein kinase pathway. In addition, the expression level of Snail1 and MMP3 was reduced, while the expression level of E-cadherin increased. These observations suggest a crucial role for cancer-associated fibroblasts and fibroblast growth factor-1\/fibroblast growth factor receptor 4 signaling in the progression of ovarian cancer. Therefore, this fibroblast growth factor-1\/fibroblast growth factor receptor 4 axis may become a potential target for the treatment of ovarian cancer.<\/jats:p>","DOI":"10.1177\/1010428317712592","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T12:20:06Z","timestamp":1500553206000},"page":"101042831771259","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":85,"title":["Cancer-associated fibroblasts secrete FGF-1 to promote ovarian proliferation, migration, and invasion through the activation of FGF-1\/FGFR4 signaling"],"prefix":"10.1177","volume":"39","author":[{"given":"Yuanzhen","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Laboratory, Laiwu Maternal and Child Health Care Hospital, Laiwu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Occupational Poisoning, Shandong Academy of Occupational Health and Occupational Medicine, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory, Shandong Provincial Hospital, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Laboratory, Laiwu Maternal and Child Health Care Hospital, Laiwu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangwei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Laboratory, Weihaiwei People\u2019s Hospital, Weihai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuimin","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Laboratory, Weihaiwei People\u2019s Hospital, Weihai, 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