{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:11:04Z","timestamp":1777929064524,"version":"3.51.4"},"reference-count":54,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tumour Biol."],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>Interleukin 12 plays an important role in immunoregulation between the T helper 1\/T helper 2 lymphocytes and in the antiviral and antitumor immune response. The aim of this study was to investigate the possible association between the interleukin 12B polymorphism rs3212227 and the risk to develop Hodgkin\u2019s lymphoma in childhood and adolescents. A total of 100 patients with Hodgkin\u2019s lymphoma and a group of 181 healthy controls were selected at random from a forensic laboratory of the University of Pernambuco. The AA genotype was detected in the controls (53.04%) and the AC genotype was found in the patients (54%). The AC genotype showed an association with the development of Hodgkin\u2019s lymphoma (odds ratio\u2009=\u20092.091, 95% confidence interval\u2009=\u20091.240\u20133.523, p\u2009=\u20090.007). When AC\u2009+\u2009CC genotypes were analyzed together, an increase in risk of 1.9 times more chances for HL development could be observed (odds ratio\u2009=\u20091.923, 95% confidence interval\u2009=\u20091.166\u20133.170, p\u2009=\u20090.014). However, there was no association between the AC and CC genotypes of the interleukin 12B polymorphism with the clinical risk group (p\u2009=\u20090.992, p\u2009=\u20090.648, respectively). Our results suggest that the presence of the C allele may be contributing to the development of Hodgkin\u2019s lymphoma in children and adolescents.<\/jats:p>","DOI":"10.1177\/1010428319860400","type":"journal-article","created":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T02:31:58Z","timestamp":1562380318000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["3\u2032 untranslated region A&gt;C (rs3212227) polymorphism of Interleukin 12B gene as a potential risk factor for Hodgkin\u2019s lymphoma in Brazilian children and adolescents"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4158-5650","authenticated-orcid":false,"given":"de Oliveira B\u00e1rbara","family":"Silva","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Biology, Pediatric Hematology Oncology Center, University of Pernambuco, Recife, Brazil"},{"name":"Biological Sciences Institute, University of Pernambuco, Recife, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nunes Amanda A","family":"Correia","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Pediatric Hematology Oncology Center, University of Pernambuco, Recife, Brazil"},{"name":"Biological Sciences Institute, University of Pernambuco, Recife, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferreira Thiago","family":"de Barros","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Pediatric Hematology Oncology Center, University of Pernambuco, Recife, Brazil"},{"name":"Faculty of Medical Sciences, University of Pernambuco, Recife, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00edsa Priscilla Oliveira","family":"de Lima","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Pediatric Hematology Oncology Center, University of Pernambuco, Recife, Brazil"},{"name":"Biological Sciences Institute, University of Pernambuco, Recife, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Morais","sequence":"additional","affiliation":[{"name":"Pediatric Outpatient Clinic, Pediatric Hematology Oncology Center, University of Pernambuco, Recife, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocio","family":"Hassan","sequence":"additional","affiliation":[{"name":"Oncovirology Laboratory, Bone Marrow Transplantation Center, National Cancer Institute of Brazil (INCA), Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edileine","family":"Dellalibera","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Pediatric Hematology Oncology Center, University of Pernambuco, Recife, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria do Socorro","family":"de Mendon\u00e7a Cavalcanti","sequence":"additional","affiliation":[{"name":"Biological Sciences Institute, University of Pernambuco, Recife, Brazil"},{"name":"Faculty of Medical Sciences, University of Pernambuco, Recife, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Tereza Cartaxo","family":"Muniz","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Pediatric Hematology Oncology Center, University of Pernambuco, Recife, Brazil"},{"name":"Biological Sciences Institute, University of Pernambuco, Recife, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,7,1]]},"reference":[{"key":"bibr1-1010428319860400","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0705-5"},{"key":"bibr2-1010428319860400","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-84842010005000085"},{"key":"bibr3-1010428319860400","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28189"},{"key":"bibr4-1010428319860400","doi-asserted-by":"crossref","unstructured":"K\u00fcppers R, Engert A, Hansmann M-L. Hodgkin lymphoma. J Clin Invest 2012; 122: 3439\u20133447, http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3534167\/pdf\/JCI61245.pdf","DOI":"10.1172\/JCI61245"},{"key":"bibr5-1010428319860400","doi-asserted-by":"crossref","unstructured":"K\u00fcppers R, Kuppers R. Molecular biology of Hodgkin lymphoma. Hematology 2009; 2009: 491\u2013496, http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20008234","DOI":"10.1182\/asheducation-2009.1.491"},{"key":"bibr6-1010428319860400","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2012.07.002"},{"key":"bibr7-1010428319860400","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu181"},{"key":"bibr8-1010428319860400","unstructured":"NCCN. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) Breast Cancer. Version3.2017, 2017, pp. 1\u2013191. www.nccn.org\/patients"},{"key":"bibr9-1010428319860400","doi-asserted-by":"crossref","unstructured":"Aldinucci D, Celegato M, Casagrande N. Mini-review: microenvironmental interactions in classical Hodgkin lymphoma and their role in promoting tumor growth, immune escape and drug resistance. Cancer Lett 2016; 380: 243\u2013252, https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26474544","DOI":"10.1016\/j.canlet.2015.10.007"},{"key":"bibr10-1010428319860400","first-page":"248","volume":"2010","author":"Aldinucci D","journal-title":"J Pathol"},{"key":"bibr11-1010428319860400","unstructured":"Pfeffer LM, Dinarello CA, Herberman RB, et al. Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons. Cancer Res 1998; 58(12): 2489\u20132499, http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9635566"},{"key":"bibr12-1010428319860400","doi-asserted-by":"crossref","unstructured":"Haik J, Nardini G, Goldman N, et al. Increased serum NKG2D-ligands and downregulation of NKG2D in peripheral blood NK cells of patients with major burns. Oncotarget 2016; 7(3): 2220\u20132228, http:\/\/www.oncotarget.com\/fulltext\/6789","DOI":"10.18632\/oncotarget.6789"},{"key":"bibr13-1010428319860400","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2008.04.007"},{"key":"bibr14-1010428319860400","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2013.14"},{"key":"bibr15-1010428319860400","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.267"},{"key":"bibr16-1010428319860400","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.272"},{"key":"bibr17-1010428319860400","doi-asserted-by":"publisher","DOI":"10.1038\/nri1863"},{"key":"bibr18-1010428319860400","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2013.111"},{"key":"bibr19-1010428319860400","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-15-0098"},{"key":"bibr20-1010428319860400","doi-asserted-by":"crossref","unstructured":"Deng W, Gowen BG, Zhang L, et al. Antitumor immunity. A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection. Science 2015; 348(6230): 136\u2013139, http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=PMC4856222","DOI":"10.1126\/science.1258867"},{"key":"bibr21-1010428319860400","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2015.07.003"},{"key":"bibr22-1010428319860400","first-page":"e366","volume":"2010","author":"Mendez-Samperio P.","journal-title":"Int J Infect Dis"},{"key":"bibr23-1010428319860400","doi-asserted-by":"crossref","unstructured":"Liu L, Xu Y, Liu Z, et al. IL12 polymorphisms, HBV infection and risk of hepatocellular carcinoma in a high-risk Chinese population. Int J Cancer 2011; 128(7): 1692\u20131696, http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20521253","DOI":"10.1002\/ijc.25488"},{"key":"bibr24-1010428319860400","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-012-1597-9"},{"key":"bibr25-1010428319860400","unstructured":"Sobota V, Bubenik J, Simova J, et al. Intratumoral IL-12 gene transfer improves the therapeutic efficacy of IL-12 but not IL-19. Folia Biol 2000; 46: 191\u2013193, http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11055798"},{"key":"bibr26-1010428319860400","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.01.030"},{"issue":"2","key":"bibr27-1010428319860400","first-page":"235","volume":"76","author":"Spitz MR","year":"1986","journal-title":"J Natl Cancer Inst"},{"key":"bibr28-1010428319860400","doi-asserted-by":"publisher","DOI":"10.3390\/ijms11030789"},{"key":"bibr29-1010428319860400","doi-asserted-by":"crossref","unstructured":"Liu J, Cao S, Kim S, et al. Interleukin-12: an update on its immunological activities, signaling and regulation of gene expression. Curr Immunol Rev 2005; 1(2): 119\u2013137, http:\/\/eutils.ncbi.nlm.nih.gov\/entrez\/eutils\/elink.fcgi?dbfrom=pubmed&id=21037949&retmode=ref&cmd=prlinks%5Cnfile:\/\/\/Users\/fingolfn\/Dropbox\/Papers2\/Articles\/2005\/Liu\/CurrImmunolRev2005Liu.pdf%5Cnpapers2:\/\/publication\/uuid\/FEBEF1E8-38BE-4018-A9CD-66182","DOI":"10.2174\/1573395054065115"},{"key":"bibr30-1010428319860400","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.08.019"},{"key":"bibr31-1010428319860400","doi-asserted-by":"crossref","unstructured":"Cozen W, Gill PS, Salam MT, et al. Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphoma. Blood 2008; 111(7): 3377\u20133382, http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=2275007&tool=pmcentrez&rendertype=abstract","DOI":"10.1182\/blood-2007-08-106872"},{"key":"bibr32-1010428319860400","unstructured":"Carbone PP, Kaplan HS, Musshoff K, et al. Report of the Committee on Hodgkin\u2019s Disease Staging Classification. Cancer Res 1971; 31: 1860\u20131861, http:\/\/cancerres.aacrjournals.org\/content\/31\/11\/1860.abstract"},{"key":"bibr33-1010428319860400","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.3.1215"},{"key":"bibr34-1010428319860400","first-page":"65","volume":"19","author":"Bonetti AM","year":"2003","journal-title":"Biosci J"},{"key":"bibr35-1010428319860400","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1829"},{"key":"bibr36-1010428319860400","first-page":"1","volume":"4","author":"Santos AA","year":"2007","journal-title":"IEEE Trans Eng Manag"},{"key":"bibr37-1010428319860400","unstructured":"MINIST\u00c9RIO DA SA\u00daDE, Instituto Nacional de C\u00e2ncer Jos\u00e9 Alencar Gomesda Silva. Estimativa 2018: Incid\u00eancia de c\u00e2ncer no Brasil2017, https:\/\/www.inca.gov.br\/sites\/ufu.sti.inca.local\/files\/\/media\/document\/\/estimativa-incidencia-de-cancer-no-brasil-2018.pdf."},{"issue":"2","key":"bibr38-1010428319860400","first-page":"141","volume":"43","author":"Dinand V","year":"2006","journal-title":"Indian Pediatr"},{"key":"bibr39-1010428319860400","doi-asserted-by":"crossref","unstructured":"Sherief LM, Elsafy UR, Abdelkhalek ER, et al. Hodgkin lymphoma in childhood: clinicopathological features and therapy outcome at 2 centers from a developing country. Medicine 2015; 94(15): e670, http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=PMC4602501","DOI":"10.1097\/MD.0000000000000670"},{"key":"bibr40-1010428319860400","doi-asserted-by":"crossref","unstructured":"Gualco G, Klumb CE, Barber GN, et al. Pediatric lymphomas in Brazil. Clinics 2010; 65(12): 1267\u20131277, http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1807-59322010001200008&lng=en&nrm=iso&tlng=en","DOI":"10.1590\/S1807-59322010001200008"},{"key":"bibr41-1010428319860400","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20487"},{"key":"bibr42-1010428319860400","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27314"},{"key":"bibr43-1010428319860400","doi-asserted-by":"crossref","unstructured":"Monteiro TAF, Arnaud MVC, Monteiro JLF, et al. Linfoma de Hodgkin: aspectos epidemiol\u00f3gicos e subtipos diagnosticados em um hospital de refer\u00eancia no Estado do Par\u00e1, Brasil. Rev Pan-amaz\u00f4nica Sa\u00fade 2016; 7: 27\u201331, http:\/\/scielo.iec.gov.br\/scielo.php?script=sciarttext&pid=S2176-62232016000100003","DOI":"10.5123\/S2176-62232016000100003"},{"key":"bibr44-1010428319860400","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2016.05.003"},{"key":"bibr45-1010428319860400","doi-asserted-by":"publisher","DOI":"10.2223\/JPED.1891"},{"key":"bibr46-1010428319860400","unstructured":"Montalban C, Garcia JF, Abraira V, et al. Influence of biologic markers on the outcome of Hodgkin\u2019s lymphoma: a study by the Spanish Hodgkin\u2019s Lymphoma Study Group. J Clin Oncol 2004; 22(9): 1664\u20131673, http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15117989"},{"key":"bibr47-1010428319860400","first-page":"583","volume":"3","author":"Zander T","year":"2002","journal-title":"Expert Rev Hematol"},{"key":"bibr48-1010428319860400","doi-asserted-by":"crossref","unstructured":"Vassilakopoulos TP, Angelopoulou MK, Constantinou N, et al. Development and validation of a clinical prediction rule for bone marrow involvement in patients with Hodgkin lymphoma. Blood 2005; 105(5): 1875\u20131880, http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15536150","DOI":"10.1182\/blood-2004-01-0379"},{"key":"bibr49-1010428319860400","doi-asserted-by":"crossref","unstructured":"Lasek W, Zagozdzon R, Jakobisiak M. Interleukin 12: still a promising candidate for tumor immunotherapy? Cancer Immunol Immunother 2014; 63(5): 419\u2013435, http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3994286&tool=pmcentrez&rendertype=abstract","DOI":"10.1007\/s00262-014-1523-1"},{"key":"bibr50-1010428319860400","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3685-7"},{"key":"bibr51-1010428319860400","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.4.869"},{"key":"bibr52-1010428319860400","doi-asserted-by":"crossref","unstructured":"Lu X. Impact of IL-12 in Cancer. Curr Cancer Drug Targets 2017; 17(8): 682\u2013697, http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28460617","DOI":"10.2174\/1568009617666170427102729"},{"key":"bibr53-1010428319860400","doi-asserted-by":"crossref","unstructured":"Sima X, Xu J, Li Q, et al. Gene-gene interactions between interleukin-12A and interleukin-12B with the risk of brain tumor. DNA Cell Biol 2012; 31(2): 219\u2013223, http:\/\/online.liebertpub.com\/doi\/abs\/10.1089\/dna.2011.1331","DOI":"10.1089\/dna.2011.1331"},{"key":"bibr54-1010428319860400","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0126614100"}],"container-title":["Tumor Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1010428319860400","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1010428319860400","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1010428319860400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:28:13Z","timestamp":1777678093000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1010428319860400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":54,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1177\/1010428319860400"],"URL":"https:\/\/doi.org\/10.1177\/1010428319860400","relation":{},"ISSN":["1010-4283","1423-0380"],"issn-type":[{"value":"1010-4283","type":"print"},{"value":"1423-0380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7]]},"article-number":"1010428319860400"}}