{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:20:51Z","timestamp":1787782851451,"version":"build-2784847793"},"reference-count":28,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2009,9,25]],"date-time":"2009-09-25T00:00:00Z","timestamp":1253836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asia Pac J Public Health"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:p>Abnormal vaginal discharge (AVD) caused by a variety of reproductive tract infections is a widespread syndrome among women in India and in other developing countries. The purpose of this study was to determine whether a polyherbal formulation, Praneem, can be used for the regression of the syndrome. A phase \u0399\u0399 randomized controlled study was carried out with Praneem polyherbal tablets and Betadine vaginal pessary in 99 women with AVD. The authors found that 92% of women using Praneem were relieved of their symptoms of AVD as against 81.6% women using Betadine. Significant reduction was also seen with both treatments in lower abdominal pain, vaginal itching, and dysuria. Thus, the study indicates the efficacy of Praneem for the treatment of AVD and provides a rationale for planning a further Phase III study on a larger sample size for definitive conclusions.<\/jats:p>","DOI":"10.1177\/1010539509344610","type":"journal-article","created":{"date-parts":[[2011,6,28]],"date-time":"2011-06-28T15:37:49Z","timestamp":1309275469000},"page":"461-468","source":"Crossref","is-referenced-by-count":3,"title":["A Phase II Randomized Controlled Trial to Evaluate the Safety and Efficacy of Praneem Polyherbal Vaginal Tablets Compared With Betadine Vaginal Pessary in Women With Symptoms of Abnormal Vaginal Discharge"],"prefix":"10.1177","volume":"21","author":[{"given":"Sudha","family":"Salhan","sequence":"first","affiliation":[{"name":"Vardhman Mahavir Medical College and Safdarjung Hospital,\rNew Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vrijesh","family":"Tripathi","sequence":"additional","affiliation":[{"name":"The University of the West Indies, St. Augustine Campus,\rTrinidad and Tobago, West Indies"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raman","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Panacea Biotec Ltd, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Kumar","sequence":"additional","affiliation":[{"name":"Vardhman Mahavir Medical College and Safdarjung Hospital,\rNew Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gursaran P.","family":"Talwar","sequence":"additional","affiliation":[{"name":"Talwar Research Foundation, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arani","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Panacea Biotec Ltd, New Delhi, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,9,25]]},"reference":[{"key":"atypb1","doi-asserted-by":"crossref","unstructured":"Koblinsky MA, Campbell OMR, Harlow SD Mother and more: a broader perspective on women\u2019s health. In: Koblinsky M, Timyan J, Gay J, eds. The Health of Women: A Global Perspective. Boulder, CO : Westview Press; 1993:33-62.","DOI":"10.4324\/9780429496455-3"},{"key":"atypb2","first-page":"251","volume":"81","author":"Bhujwala RA","year":"1985","journal-title":"Ind J Med Res"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91438-4"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-4820-8_10"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(94)00367-M"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.5.1656S"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(92)91628-N"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.5.1589S"},{"key":"atypb9","first-page":"163","volume":"38","author":"Klufio CA","year":"1995","journal-title":"P N G Med J"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2005.05.007"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.1.e13"},{"key":"atypb12","unstructured":"Talwar GP, Garg S., Singh R., et al. Praneem polyherbal cream and suppositories. In: Mauck DK, Cordero M, Gabelnick HL, Spieler JF , Rivera R, eds. Barrier Contraceptives: Current Status and Future Prospects. New York, NY: Wiley-Liss; 1994:273-276."},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1111\/j.8755-8920.2000.430303.x"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1995.tb01867.x"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2006.01.008"},{"key":"atypb16","volume-title":"Paper presented at: Microbicides Conference","author":"Hazari K."},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2005.01.007"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1185\/03007997509113664"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(87)90155-9"},{"key":"atypb20","unstructured":"Yu H, Tak-Yin M. The efficacy of povidone-iodine pessaries in a short, low-dose treatment regime on candidal, trichomonal and non-specific vaginitis. Postgrad Med J. 1993;69(suppl 3):S58-S61. 21. World Health Organization. Guidelines for the management of sexually transmitted infections. http:\/\/www.popline.org\/docs\/1596\/191663.html. Published 2003. Accessed July 21, 2009."},{"key":"atypb21","first-page":"1716","volume":"60","author":"Woodward C.","year":"1999","journal-title":"Am Fam Physician."},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.8.949"},{"key":"atypb23","first-page":"443","volume":"41","author":"Ferris DG","year":"1995","journal-title":"J Fam Pract"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.2174\/1568011053174828"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2003.10.016"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(89)90111-X"},{"key":"atypb27","first-page":"135","volume":"113","author":"Raghuvanshi P.","year":"2001","journal-title":"Ind J Med Res"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(94)90054-X"}],"container-title":["Asia Pacific Journal of Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1010539509344610","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1010539509344610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:39:01Z","timestamp":1777376341000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1010539509344610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,25]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["10.1177\/1010539509344610"],"URL":"https:\/\/doi.org\/10.1177\/1010539509344610","relation":{},"ISSN":["1010-5395","1941-2479"],"issn-type":[{"value":"1010-5395","type":"print"},{"value":"1941-2479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,25]]}}}