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Then, a novel serological tool, designated Typhidot-C, was evaluated in retrospect using the detected individuals as control positives. Chronic carriage positive by the culture and polymerase chain reaction method was recorded at 3.6% (4 out of 110) among individuals who previously had acute typhoid fever and a 9.4% (10 out of 106) carriage rate was observed among food handlers screened during outbreaks. The Typhidot-C assay was able to detect all these positive carriers showing its potential as a viable carrier screening tool and can be used for efficient detection of typhoid carriers in an endemic area. These findings were used to establish the first carrier registry for S Typhi carriers in Malaysia.<\/jats:p>","DOI":"10.1177\/1010539512458521","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T20:27:27Z","timestamp":1348259247000},"page":"NP2740-NP2748","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Identification of Carriers Among Individuals Recruited in the Typhoid Registry in Malaysia Using Stool Culture, Polymerase Chain Reaction, and Dot Enzyme Immunoassay as Detection Tools"],"prefix":"10.1177","volume":"27","author":[{"given":"Ang Lim","family":"Chua","sequence":"first","affiliation":[{"name":"Universiti Sains Malaysia, Kubang Kerian, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Aziah","sequence":"additional","affiliation":[{"name":"Universiti Sains Malaysia, Kubang Kerian, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabha","family":"Balaram","sequence":"additional","affiliation":[{"name":"Universiti Sains Malaysia, Kubang Kerian, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saatheeyavaane","family":"Bhuvanendran","sequence":"additional","affiliation":[{"name":"Universiti Sains Malaysia, Kubang Kerian, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy Amilda","family":"Anthony","sequence":"additional","affiliation":[{"name":"Universiti Sains Malaysia, Kubang Kerian, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siti Norazura","family":"Mohmad","sequence":"additional","affiliation":[{"name":"Universiti Sains Malaysia, Kubang Kerian, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norhafiza M.","family":"Nasir","sequence":"additional","affiliation":[{"name":"Universiti Sains Malaysia, Kubang Kerian, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haslizai","family":"Hassan","sequence":"additional","affiliation":[{"name":"Universiti Sains Malaysia, Kubang Kerian, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rochman","family":"Naim","sequence":"additional","affiliation":[{"name":"Universiti Sains Malaysia, Kubang Kerian, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lila P.","family":"Meran","sequence":"additional","affiliation":[{"name":"Ministry of Health, Kota Bharu, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hani M.","family":"Hussin","sequence":"additional","affiliation":[{"name":"Ministry of Health, Kota Bharu, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asma","family":"Ismail","sequence":"additional","affiliation":[{"name":"Universiti Sains Malaysia, Kubang Kerian, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,9,20]]},"reference":[{"key":"bibr1-1010539512458521","first-page":"346","volume-title":"Bull World Health Organ","volume":"82","author":"Crump JA","year":"2004"},{"key":"bibr2-1010539512458521","doi-asserted-by":"publisher","DOI":"10.1177\/101053959700900101"},{"key":"bibr3-1010539512458521","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.06.039818"},{"key":"bibr4-1010539512458521","doi-asserted-by":"publisher","DOI":"10.1177\/101053958700100112"},{"key":"bibr5-1010539512458521","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-10-45"},{"key":"bibr6-1010539512458521","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/146.6.724"},{"key":"bibr7-1010539512458521","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2490"},{"key":"bibr8-1010539512458521","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-6553(85)80013-4"},{"key":"bibr9-1010539512458521","unstructured":"World Health Organization. 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