{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:46:18Z","timestamp":1777430778406,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T00:00:00Z","timestamp":1697241600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Asia Pac J Public Health"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>Betel quid (BQ) is commonly used in the Asia-Pacific region. Disulfiram is prescribed for people with alcohol use disorders (PwAUDs) after the completion of detoxification as an alternative to rehabilitation. This prospective observational study reported the aversive reactions and common symptoms of disulfiram and BQ in PwAUDs. Participants included PwAUDs admitted to the psychiatric ward at the Jigme Dorji Wangchuck National Referral Hospital for detoxification, who were on Disulfiram and using BQ at the same time. Aversive reactions between disulfiram and BQ were observed for 100 patients over a year. Twenty participants showed aversive reactions between BQ and disulfiram. Common symptoms included sweating, diarrhea, dizziness, tremors, palpitations, shortness of breath, nausea and vomiting, and headache. Since PwAUDs in Bhutan are inducted on disulfiram after detoxification, and most use BQ simultaneously, this study will help inform health care providers to educate people about the aversive reactions of disulfiram and BQ.<\/jats:p>","DOI":"10.1177\/10105395231204801","type":"journal-article","created":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T06:38:07Z","timestamp":1697265487000},"page":"532-534","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Aversive Reaction Between Disulfiram and Betel Quid Among Inpatients With Alcohol Use Disorder in Bhutan: A Preliminary Study"],"prefix":"10.1177","volume":"35","author":[{"given":"Ugyen","family":"Dem","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zimba","family":"Letho","sequence":"additional","affiliation":[{"name":"Faculty of Nursing and Public Health, Khesar Gyalpo University of Medical Sciences of Bhutan, Thimphu, Bhutan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chencho","family":"Dorji","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damber K.","family":"Nirola","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonam","family":"Choki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tashi","family":"Dorji","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6713-7421","authenticated-orcid":false,"given":"Pelden","family":"Chejor","sequence":"additional","affiliation":[{"name":"Centre for Research in Aged Care, Edith Cowan University, Joondalup, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,10,14]]},"reference":[{"key":"bibr1-10105395231204801","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2203571"},{"key":"bibr2-10105395231204801","unstructured":"World Health Organization for the Western Pacific. Review of areca (betel) nut and tobacco use in the Pacific: a technical report. Published 2012. Accessed August 12, 2023. https:\/\/apps.who.int\/iris\/handle\/10665\/206910"},{"key":"bibr3-10105395231204801","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5851.133702"},{"key":"bibr4-10105395231204801","doi-asserted-by":"publisher","DOI":"10.1177\/00220345221092751"},{"key":"bibr5-10105395231204801","doi-asserted-by":"publisher","DOI":"10.4103\/IJPSYM.IJPSYM_412_18"},{"key":"bibr6-10105395231204801","unstructured":"Dorji L. Alcohol Use and Abuse in Bhutan (Monograph Series I). 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