{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T14:29:48Z","timestamp":1792765788195,"version":"4.5.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Orthop Surg (Hong Kong)"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The purpose of this meta-analysis was to compare the efficacy and imaging parameters of kinematic alignment (KA) and mechanical alignment (MA) in total knee arthroplasty (TKA) and to evaluate whether patients undergoing KA-TKA benefited more than those undergoing MA-TKA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Studies comparing the efficacy of KA-TKA and MA-TKA were included after searching and screening in the database, including PubMed, Embase, Web of Science and Cochrane Database Library. A total of 1420 patients were enrolled in the study, with 736 MA-TKA and 738 KA-TKA. The primary outcomes were postoperative knee function scores including KSS series, WOMAC, KOOS and OKS. Secondary outcomes included the operative time, the length of hospital stay, knee extension\/flexion angle, and some imaging parameters. The risk of bias for included studies was assessed using the Cochrane Collaborative risk-of-bias assessment tool or the Newcastle-Ottawa Scale(NOS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixteen studies were included in this meta-analysis (11 randomized controlled studies and 5 cohort studies). Primary outcomes: Knee Society score (KSS, MD = 8.36, 95% Cl: 0.83\u201315.90) and combined KSS (MD = 15.24, 95% CI: 5.41\u201325.07) were higher in KA-TKA than in MA-TKA, and other functional scores were not statistically significant in KA-TKA and MA-TKA, including knee injury and osteoarthritis outcome score (KOOS), Oxford knee score (OKS), Knee Function score (KFS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Secondary outcomes: KA-TKA resulted in smaller medial proximal tibial angle (MPTA) and lateral distal femoral angle (LDFA) compared to MA-TKA. For other outcome measures, KA-TKA showed similar results compared to MA-TKA, including hip-knee-ankle (HKA) angle, extension\/flexion angle, tibial component slope angle, joint line orientation angle (JLOA), the operation time, the length of hospital stay and ligament release rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In our analysis results, patients undergoing KA-TKA benefit as much as patients undergoing MA-TKA. KA may be a viable reference in total knee replacement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10225536221125952","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T05:39:42Z","timestamp":1665985182000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":50,"title":["Kinematic alignment versus mechanical alignment in total knee arthroplasty: An up-to-date meta-analysis"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6663-9665","authenticated-orcid":false,"given":"Gengshuang","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Joint Surgery, North China Medical&Health Group XingTai General Hospital, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Joint Surgery, North China Medical&Health Group XingTai General Hospital, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linzhou","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Joint Surgery, North China Medical&Health Group XingTai General Hospital, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Joint Surgery, North China Medical&Health Group XingTai General Hospital, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixiong","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Joint Surgery, North China Medical&Health Group XingTai General Hospital, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianpeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Joint Surgery, North China Medical&Health Group XingTai General Hospital, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"bibr1-10225536221125952","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198501000-00003"},{"key":"bibr2-10225536221125952","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198303000-00024"},{"key":"bibr3-10225536221125952","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.I.01398"},{"key":"bibr4-10225536221125952","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-1119-9"},{"key":"bibr5-10225536221125952","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20080901-15"},{"key":"bibr6-10225536221125952","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-011-1936-5"},{"issue":"2","key":"bibr7-10225536221125952","first-page":"71","volume":"87","author":"Eckhoff DG","year":"2005","journal-title":"J Bone Joint Surg 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