{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:46:01Z","timestamp":1780587961488,"version":"3.54.1"},"reference-count":32,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"2022 \u201cYouth Science Project Technical Talents - Rural Revitalization\u201d Project of Autonomous Region","award":["WJWY-XCZX202209"],"award-info":[{"award-number":["WJWY-XCZX202209"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Orthop Surg (Hong Kong)"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Osteoporosis (OP) is a widespread disease that causes risks of spine and hip fractures. Morinda officinalis polysaccharide (MOP) shows therapeutic potential in OP. This article intended to understand the mechanism by which MOP impacts bone mineral density (BMD) and serum trace elements in OP rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>OP rat models were established by bilateral ovariectomy (OVX). Rats were intragastrically administered with MOP or ZLN005 [the activator of peroxisome proliferator-activated receptor-\u03b3 coactivator-1\u03b1 (PGC-1\u03b1)] since the first day after operation for 8 weeks. Microstructural changes in OP rats were analyzed using micro-computed tomography system. Contents of serum Zn, Cu, Fe, and Mg in rats were measured. Levels of serum superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), GSH, and malondialdehyde (MDA) in rats were determined by Enzyme-linked immunosorbent assay. Protein levels of PGC-1\u03b1 and peroxisome proliferator-activated receptor \u03b3 (PPAR\u03b3) in cartilage tissues of rats were determined via Western blotting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MOP enhanced BMD, bone volume per trabecular volume (BV\/TV), Tb.N, and Tb.Th and reduced Tb.Sp in the distal femur of OVX rats, elevated levels of serum Cu, Fe, and Mg and contents of SOD, GSH, and GSH-PX and decreased MDA content. Moreover, MOP suppressed the PGC-1\u03b1\/PPAR\u03b3 pathway. Activation of PGC-1\u03b1 partially abolished the action of MOP on ameliorating OP in OVX rats and strengthening anti-oxidation ability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MOP mitigated OP in OVX rats by inhibiting the PGC-1\u03b1\/PPAR\u03b3 pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10225536221130824","type":"journal-article","created":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:27:02Z","timestamp":1668212822000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Morinda officinalis polysaccharide attenuates osteoporosis in rats underwent bilateral ovariectomy by suppressing the PGC-1\u03b1\/PPAR\u03b3 pathway"],"prefix":"10.1177","volume":"30","author":[{"given":"Kai","family":"Rong","sequence":"first","affiliation":[{"name":"Department of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingbo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Traumatology, Hospital of Traditional Chinese Medicine Affiliated to Xinjiang Medical University, Wulumuqi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Traumatology, Hospital of Traditional Chinese Medicine Affiliated to Xinjiang Medical University, Wulumuqi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaowu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Traumatology, Hospital of Traditional Chinese Medicine Affiliated to Xinjiang Medical University, Wulumuqi, 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