{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:25:54Z","timestamp":1789496754265,"version":"build-2803163510"},"reference-count":58,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Sanming Project of Medicine in Shenzhen, China","award":["No. SZSM201612055"],"award-info":[{"award-number":["No. SZSM201612055"]}]},{"name":"HKU-SZH Fund for Shenzhen Key Medical Discipline","award":["No. SZXK2020084"],"award-info":[{"award-number":["No. SZXK2020084"]}]},{"name":"Shenzhen Fundamental Research Program, China","award":["No. JCYJ20180306173518936"],"award-info":[{"award-number":["No. JCYJ20180306173518936"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Orthop Surg (Hong Kong)"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Over the past 12\u00a0years, vertebral body tethering (VBT) has been gradually promoted for treating scoliosis, but there are few published studies, with only short-term follow-up. This study aimed to systematically review VBT efficacy and safety for treating scoliosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Web of Science, Embase, and the Cochrane Library were searched for studies on VBT treatment of scoliosis published up to November 2021. Two researchers independently screened the literature, extracted data, and assessed the risk of bias in included studies. Data on clinical efficacy, unplanned reoperations, and complications were extracted. The meta-analysis was performed with R 4.1.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-six studies involving 1045 patients were included in the meta-analysis. The correction rate of major curve immediately post-operation was 46.6% \u00b1 13.8% (16%\u201369%) and that at final follow-up was 53.2% \u00b1 17.9% (16%\u201379%). The single-arm meta-analysis results of all included studies showed that VBT was effective in general. The overall clinical success rate was 73.02% (95% confidence interval [CI]: 68.31%\u201378.05%). The pooled overall unplanned reoperation rate was 8.66% (95% CI: 5.53%\u201313.31%). The overall incidence rate of complications was 36.8% (95% CI: 23.9%\u201349.7%). The subgroup analysis based on follow-up time indicated that patients with follow-up time &gt;36 months had increased clinical success rate, unplanned reoperation rate, and incidence rate of complications compared with those with &lt;36 months\u2019 follow-up time. The preliminary results showed that after 36 months of follow-up, only 7.17% (95% CI: 4.81%\u201310.55%) of patients required posterior spinal fusion (PSF) surgery and nearly 93% of patients avoided spinal fusion surgeries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The current evidence from at least 3-year follow-up in different countries indicates that VBT is an effective surgical approach for treating scoliosis, with 73.88% of patients achieving clinical success. Nevertheless, about one in seven patients (15.8%) required unplanned reoperations, but only 7.17% required PSF. About half (52.17%) of the patients experienced complications. Due to the limitation of the study number and quality, our conclusion may be biased and requires verification by further studies with longer follow-up times.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10225536221137753","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T12:34:35Z","timestamp":1669293275000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Minimum 3-year experience with vertebral body tethering for treating scoliosis: A systematic review and single-arm meta-analysis"],"prefix":"10.1177","volume":"30","author":[{"given":"Feng","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Spinal Surgery, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China"},{"name":"Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, 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