{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:15:11Z","timestamp":1777929311731,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072427"],"award-info":[{"award-number":["82072427"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Yongkang","award":["201721"],"award-info":[{"award-number":["201721"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Orthop Surg (Hong Kong)"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Osteoprotegerin (OPG) and bone morphogenetic protein-2 (BMP-2) could be administered sequentially to promote tendon-bone healing. There remain several unresolved issues in our previously published study: a) the release kinetics of OPG\/BMP-2 from the OPG\/BMP-2\/collagen sponge (CS) combination in vitro remained unclear; b) the medium-term effect of the OPG\/BMP-2\/CS combination was not analyzed. Hence, we design this study to address the issues mentioned above.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>30 rabbits undergoing anterior cruciate ligament reconstruction (ACLR) with an Achilles tendon autograft randomly received one of the 3 delivery at the femoral and tibial tunnels: OPG\/BMP-2, OPG\/BMP-2\/CS combination, and nothing (blank control). At 8 and 24 weeks post-surgery, the biomechanical tests and histologic analysis were used to evaluate the tendon-bone healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In mechanical tests, the OPG\/BMP-2\/CS group showed a higher final failure load and stiffness than the other groups at 8 and 24 weeks. Additionally, the maximum stretching distance showed a decreasing trend. The mechanical failure pattern of samples shifted from a tunnel pull-away to a graft midsubstance rupture after OPG\/BMP-2\/CS-treated. From histological analysis, the OPG\/BMP-2\/CS treatment increased the amount of collagen fibers (collagen I and II) and promoted fibrocartilage attachment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CS as a carrier promotes the medium-term effect of OPG and BMP-2 on tendon-bone healing at the tendon-bone interface in a rabbit ACLR model. OPG, BMP-2 and CS were already applied in several clinical practice, but a further study of clinic use of OPG\/BMP-2\/CS is still needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10225536231163467","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T18:15:56Z","timestamp":1678385756000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Investigation of the medium-term effect of osteoprotegerin\/bone morphogenetic protein 2 combining with collagen sponges on tendon-bone healing in a rabbit"],"prefix":"10.1177","volume":"31","author":[{"given":"Bing","family":"Wei","sequence":"first","affiliation":[{"name":"School of Medicine, Southeast University, Nanjing, China"},{"name":"Department of Orthopaedic Surgery\/Joint and Sports Medicine Center, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 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