{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:10:01Z","timestamp":1787019001878,"version":"build-2736575974"},"reference-count":46,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Orthop Surg (Hong Kong)"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>Background: Duloxetine is a serotonin and norepinephrine reuptake inhibitor (SNRI) with clinical efficacy in chronic pain conditions. In this study, we aim to evaluate the analgesic effect and safety of duloxetine in total knee arthroplasty (TKA). Methods: A systematic search was completed on MEDLINE, PsycINFO, and Embase from inception to December 2022 to find relevant articles. We used Cochrane methodology to evaluate the bias of included studies. Investigated outcomes included postoperative pain, opioid consumption, adverse events (AEs), range of motion (ROM), emotional and physical function, patient satisfaction, patient-controlled analgesia (PCA), knee-specific outcomes, wound complications, skin temperature, inflammatory markers, length of stay, and incidence of manipulations. Results: Nine articles involving 942 participants were included in our systematic review. Out of nine papers, eight were randomized clinical trials and one was a retrospective study. The results of these studies indicated the analgesic effect of duloxetine on postoperative pain, which was measured using numeric rating scale and visual analogue scale. Deluxetine was also effective in reducing the morphine requirement and wound complications and enhancing patient satisfaction after surgery. However, the results on ROM, PCA, and knee-specific outcomes were contraventional. Deluxetine was generally safe without serious AEs. The most common AEs included headache, nausea, vomiting, dry mouth, and constipation. Conclusion: Duloxetine may be an effective treatment option for postoperative pain following TKA, but further rigorously designed and well-controlled randomized trials are required.<\/jats:p>","DOI":"10.1177\/10225536231177482","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T18:01:15Z","timestamp":1686074475000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["The analgesic effect and safety of duloxetine in total knee arthroplasty: A systematic review"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9526-468X","authenticated-orcid":false,"given":"Emad","family":"Kouhestani","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran"},{"name":"Bone Joint and Related Tissues Research Center, Akhtar Orthopedic Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Minaei","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran"},{"name":"Bone Joint and Related Tissues Research Center, Akhtar Orthopedic Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Salimi","sequence":"additional","affiliation":[{"name":"School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoosef","family":"Mehrabi","sequence":"additional","affiliation":[{"name":"School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakila","family":"Meshkat","sequence":"additional","affiliation":[{"name":"School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"key":"bibr1-10225536231177482","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.J.01958"},{"key":"bibr2-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.92B9.24394"},{"key":"bibr3-10225536231177482","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200704000-00012"},{"key":"bibr4-10225536231177482","doi-asserted-by":"publisher","DOI":"10.4055\/cios.2017.9.3.303"},{"key":"bibr5-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2013.10.001"},{"key":"bibr6-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocl.2017.05.001"},{"key":"bibr7-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1111\/os.12535"},{"key":"bibr8-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/78.5.606"},{"issue":"4","key":"bibr9-10225536231177482","first-page":"106","volume":"36","author":"Nemeroff CB","year":"2002","journal-title":"Psychopharmacol Bull"},{"key":"bibr10-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1080\/10401230701333319"},{"key":"bibr11-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1586\/eci.10.64"},{"key":"bibr12-10225536231177482","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S17428"},{"key":"bibr13-10225536231177482","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2018.460"},{"key":"bibr14-10225536231177482","first-page":"CD007115","volume":"1","author":"Lunn MP","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr15-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12800"},{"key":"bibr16-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afs072"},{"key":"bibr17-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"bibr18-10225536231177482","volume-title":"Cochrane handbook for systematic reviews of interventions","author":"Thomas J","year":"2019"},{"key":"bibr19-10225536231177482","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10132809"},{"key":"bibr20-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-052944"},{"key":"bibr21-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2022.02.022"},{"key":"bibr22-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001228"},{"key":"bibr23-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq158"},{"key":"bibr24-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-022-05194-z"},{"key":"bibr25-10225536231177482","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.18.00347"},{"key":"bibr26-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0253641"},{"key":"bibr27-10225536231177482","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-77484\/v1"},{"key":"bibr28-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-020-01216-9"},{"key":"bibr29-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2020.03.001"},{"key":"bibr30-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017541"},{"key":"bibr31-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1097\/wnf.0b013e3180340319"},{"key":"bibr32-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.45.1.17"},{"key":"bibr33-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.2813"},{"key":"bibr34-10225536231177482","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v65n0411"},{"key":"bibr35-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.12.001"},{"key":"bibr36-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2014.05.011"},{"key":"bibr37-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(02)00009-6"},{"key":"bibr38-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)63824-8"},{"key":"bibr39-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1990.tb16906.x"},{"key":"bibr40-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.070656"},{"key":"bibr41-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.04.006"},{"key":"bibr42-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2016.12.025"},{"key":"bibr43-10225536231177482","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6610a1"},{"key":"bibr44-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pny150"},{"issue":"3","key":"bibr45-10225536231177482","first-page":"63","volume":"75","author":"Stephan BC","year":"2016","journal-title":"Hawaii J Med Pub Health"},{"key":"bibr46-10225536231177482","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2011.10.014"}],"container-title":["Journal of Orthopaedic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10225536231177482","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10225536231177482","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10225536231177482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:30:30Z","timestamp":1777678230000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10225536231177482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1177\/10225536231177482"],"URL":"https:\/\/doi.org\/10.1177\/10225536231177482","relation":{},"ISSN":["1022-5536","2309-4990"],"issn-type":[{"value":"1022-5536","type":"print"},{"value":"2309-4990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5]]},"article-number":"10225536231177482"}}