{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:13:57Z","timestamp":1777929237503,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Study on bone markers and osteoporosis in postmenopausal women in Guizhou Province","award":["NO.gzwkj2022\/179"],"award-info":[{"award-number":["NO.gzwkj2022\/179"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Orthop Surg (Hong Kong)"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Serotonin (5-HT) precursors regulate bone remodeling. This study aims to investigate the correlation of plasma 5-HT precursors and metabolite with bone mineral density (BMD) and bone turnover markers in postmenopausal osteoporosis (PMOP) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The age, body mass index (BMI), and years since menopause (YSM) were documented for 348 postmenopausal women in normal\/osteopenia\/osteoporosis (OP) groups, with lumbar spine and femoral neck BMD measured. Serum bone turnover markers (PINP\/\u03b2-CTX) and plasma 5-HT, 5-HT precursors (Trp\/5-HTP) and metabolite (5-HIAA) were measured by ELISA. OP patients were allocated to high\/low expression groups following ROC analysis of 5-HT\/Trp\/5-HTP\/5-HIAA. The relationship of plasma 5-HT\/Trp\/5-HTP\/5-HIAA, BMD, and bone turnover markers with PMOP was analyzed using logistic regression analysis. The correlation of plasma 5-HT\/Trp\/5-HTP\/5-HIAA with BMD and bone turnover markers was analyzed using Pearson\u2019s correlation analysis, followed by logistic regression analysis of the relationship between plasma 5-HT\/Trp\/5-HTP\/5-HIAA and BMD, bone turnover markers and PMOP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>BMI, YSM, BMD and PINP, and \u03b2-CTX levels differed among groups. Levels of plasma 5-HT precursors\/metabolite were increased in OP patients. Individuals with high 5-HT precursors\/metabolite levels had low BMD and high PINP\/\u03b2-CTX levels. The 5-HT precursors\/metabolite negatively-correlated with BMD and positively-correlated with PINP\/\u03b2-CTX. BMI, YSM, BMD, and PINP\/\u03b2-CTX\/Trp\/5-HTP\/5-HT related to PMOP and were independent risk factors for OP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Plasma 5-HT precursors and metabolite negatively-correlate with BMD and positively-correlate with PINP\/\u03b2-CTX in PMOP patients. Peripheral 5-HT precursors and metabolite level may be a new direction of treatment of PMOP and bone metabolism-related disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10225536231187181","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T06:14:13Z","timestamp":1712988853000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasma serotonin precursors and metabolite are correlated with bone mineral density and bone turnover markers in patients with postmenopausal osteoporosis"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8581-6054","authenticated-orcid":false,"given":"Qinying","family":"Feng","sequence":"first","affiliation":[{"name":"Central Laboratory, Beijing Jishuitan Hospital Guizhou Hospital, Guiyang, 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