{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:07:57Z","timestamp":1783480077881,"version":"3.55.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Competitive State Financing of the Expert Responsibility Area of Tampere University Hospital"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Orthop Surg (Hong Kong)"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To understand the systemic effect of major spine surgery, we investigated stress, anabolic and catabolic hormonal levels and their association with interleukin 6 (IL-6) in patients undergoing elective lumbar spine fusion surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Blood samples were collected preoperatively, and at 1, 3, 42, 90\u00a0days postoperatively (POD) from 49 patients who underwent elective lumbar spine fusion surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum concentration of cortisol was below the preoperative value at POD 1 but did not differ from the baseline values thereafter. Adrenocorticotropic hormone (ACTH) decreased at PODs 1 and 3. Testosterone decreased at PODs 1 and 3 in men, and at POD 3 in women. Sex hormone-binding globulin decreased at PODs 1 and 3 in both genders. No changes were observed in free testosterone or growth hormone concentrations. Insulin-like growth factor 1 increased significantly above the preoperative level at PODs 42 and 90 in women, and at POD 42 in men. IL-6 was significantly elevated at PODs 1 and 3. Increases in IL-6 from the preoperative level to POD 1 correlated significantly with decreases of cortisol at POD 1 but not with ACTH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There were only short-term stress hormonal changes after elective lumbar spine fusion surgery. Cortisol changes after elective lumbar spine surgery are transient and might be partly cytokine induced and non-ACTH driven since there was association between cortisol and IL-6 but not with ACTH and IL-6.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10225536231201910","type":"journal-article","created":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T04:37:48Z","timestamp":1697863068000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Stress hormone response to instrumented elective lumbar spine fusion surgery"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4688-5698","authenticated-orcid":false,"given":"Jussi P","family":"Repo","sequence":"first","affiliation":[{"name":"Unit of Musculoskeletal Diseases, Department of Orthopaedic, Tampere University Hospital, Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko 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Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arja H","family":"H\u00e4kkinen","sequence":"additional","affiliation":[{"name":"Health Sciences, Faculty of Sport and Health Sciences, University of Jyv\u00e4skyl\u00e4, Jyv\u00e4skyl\u00e4, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,10,21]]},"reference":[{"issue":"4","key":"bibr1-10225536231201910","first-page":"1238","volume":"80","author":"Vermes I","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"bibr2-10225536231201910","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214969"},{"key":"bibr3-10225536231201910","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2008.01.009"},{"issue":"11","key":"bibr4-10225536231201910","first-page":"368","volume":"29","author":"Kapritsou M","year":"2018","journal-title":"J Perioper 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