{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:14:22Z","timestamp":1777929262407,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072501"],"award-info":[{"award-number":["82072501"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Hunan Provincial Natural Science Foundation project","award":["2023JJ50247"],"award-info":[{"award-number":["2023JJ50247"]}]},{"name":"The Research Program of the Health Commission of Hunan Province","award":["D202304076870"],"award-info":[{"award-number":["D202304076870"]}]},{"name":"The Science and Technology Program of Shaoyang City","award":["2021071ZD"],"award-info":[{"award-number":["2021071ZD"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Orthop Surg (Hong Kong)"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Platelet-rich plasma treatment delays the need for total knee replacement in patients with knee osteoarthritis. However, its use and preparation remain controversial. The aim of this study was to investigate the relationship between anticoagulant use in the preparation of platelet-rich plasma and post-treatment pain in patients with knee osteoarthritis. Additionally, we explored the efficacy of platelet-rich plasma over medium- and long-term follow-up periods and identified other factors that may affect treatment outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, 225 patients with knee osteoarthritis, who underwent knee platelet-rich plasma treatment from June 2021 to January 2022, were examined at three study centres. Patients were categorised, based on the type and amount of anticoagulant used during platelet-rich plasma preparation, into 4% sodium citrate (SC) 0.6\u00a0mL, 4% SC 1\u00a0mL, 4% SC 2\u00a0mL, heparin 0.1\u00a0mL, and heparin 0.2\u00a0mL groups. We analysed the patients\u2019 basic information, pain after treatment, and inflammatory markers (i.e., interleukin 6, tumour necrosis factor-\u03b1, and hypersensitive C-reactive protein) in the joint fluid via enzyme-linked immunosorbent assay and joint fluid crystallisation. Additionally, we assessed the patients\u2019 Western Ontario and McMaster University scores and minimal clinically significant differences after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients in the 4% SC 0.6\u00a0mL and heparin 0.1\u00a0mL groups experienced less pain after platelet-rich plasma treatment than did patients in the high-dose anticoagulant group. The joint fluid of patients with pain in these groups had lower levels of inflammatory markers. Patients treated with SC had slightly better medium- and long-term therapeutic outcomes than did patients treated with heparin. Patients with poorly controlled hyperuricemia also experienced pain after platelet-rich plasma treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results suggest that platelet-rich plasma prepared using high-dose anticoagulants or administered to patients with poorly controlled hyperuricaemia may lead to moderate-to-severe knee pain and joint effusion after joint puncture therapy. Platelet-rich plasma had a therapeutic effect on knee osteoarthritis; however, its efficacy gradually decreased over time. SC anticoagulant is more suitable for platelet-rich plasma preparation than is heparin. Further studies are needed to understand the safety and the various factors influencing platelet-rich plasma therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10225536241277604","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T02:49:10Z","timestamp":1724035750000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Inadequate anticoagulation and hyperuricemia cause knee pain after platelet-rich plasma injection: A retrospective study"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5476-0847","authenticated-orcid":false,"given":"Yang","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Shenzhen Hospital, Southern Medical University, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxun","family":"Sang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Shenzhen Hospital, Southern Medical University, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Third Xiangya Hospital of Central South University, Changsha, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haobin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Central Hospital of Shaoyang, Shaoyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Central Hospital of Shaoyang, Shaoyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Central Hospital of Shaoyang, Shaoyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,8,18]]},"reference":[{"key":"bibr1-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60802-3"},{"key":"bibr2-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocarto.2023.100344"},{"key":"bibr3-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-022-06150-x"},{"key":"bibr4-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2022.2088530"},{"key":"bibr5-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201900278"},{"key":"bibr6-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-020-04669-9"},{"key":"bibr7-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1177\/19476035221118419"},{"key":"bibr8-10225536241277604","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115492"},{"key":"bibr9-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1002\/pmrj.12561"},{"key":"bibr10-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2021.101646"},{"key":"bibr11-10225536241277604","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020890"},{"key":"bibr12-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-021-04230-2"},{"key":"bibr13-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2022.06.004"},{"key":"bibr14-10225536241277604","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.16.01374"},{"key":"bibr15-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3852898"},{"key":"bibr16-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.28500"},{"key":"bibr17-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1016\/S1297-319X(01)00337-2"},{"key":"bibr18-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-021-04706-7"},{"key":"bibr19-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/lmab090"},{"key":"bibr20-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1186\/scrt218"},{"key":"bibr21-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(00)90058-2"},{"key":"bibr22-10225536241277604","first-page":"e57700","volume":"143","author":"Chen Z","year":"2019","journal-title":"J Vis Exp"},{"key":"bibr23-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2021.09.013"},{"key":"bibr24-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1177\/03635465211062243"},{"key":"bibr25-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0249797"},{"key":"bibr26-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-019-01541-z"},{"key":"bibr27-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000001856"},{"key":"bibr28-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.11.032"},{"key":"bibr29-10225536241277604","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021512"},{"key":"bibr30-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1097\/CORR.0000000000002264"},{"key":"bibr31-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1177\/0363546516665809"},{"key":"bibr32-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1761865"},{"key":"bibr33-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00569-9"},{"key":"bibr34-10225536241277604","first-page":"1215","volume":"32","author":"Spartalis E","year":"2018","journal-title":"J Biol Regul Homeost Agents"},{"key":"bibr35-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2023.03.001"},{"key":"bibr36-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.19415"},{"key":"bibr37-10225536241277604","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13040760"},{"key":"bibr38-10225536241277604","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10194514"},{"key":"bibr39-10225536241277604","doi-asserted-by":"publisher","DOI":"10.1302\/2058-5241.6.200017"}],"container-title":["Journal of Orthopaedic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10225536241277604","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10225536241277604","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10225536241277604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:31:39Z","timestamp":1777678299000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10225536241277604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1177\/10225536241277604"],"URL":"https:\/\/doi.org\/10.1177\/10225536241277604","relation":{},"ISSN":["1022-5536","2309-4990"],"issn-type":[{"value":"1022-5536","type":"print"},{"value":"2309-4990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]},"article-number":"10225536241277604"}}