{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T02:41:03Z","timestamp":1779936063555,"version":"3.53.1"},"reference-count":35,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021QH307"],"award-info":[{"award-number":["ZR2021QH307"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jinan Clinical Medical Science and Technology Innovation Plan","award":["202328065"],"award-info":[{"award-number":["202328065"]}]},{"name":"Shandong Province Major Scientific and Technical Innovation Project","award":["2021SFGC0502"],"award-info":[{"award-number":["2021SFGC0502"]}]},{"name":"Shandong Traditional Chinese Medicine Science and Technology Development Plan Project","award":["2019-0301"],"award-info":[{"award-number":["2019-0301"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Orthop Surg (Hong Kong)"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The study aims to evaluate the influence of tranexamic acid (TXA) on clinical outcomes in patients with elbow stiffness undergoing elbow arthrolysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review of records up to December 2024 was conducted to screen research examining the role of TXA in patients with elbow stiffness undergoing elbow arthrolysis. The primary outcomes of interest included blood transfusion, hematoma formation, operative time, postoperative pain measured by the Mayo Elbow Performance Score (MEPS), Visual Analog Scale (VAS), total blood loss, changes in hemoglobin, drain output, and complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Following an extensive search of relevant databases, a total of seven studies involving 995 patients (491 in the TXA group and 504 in the non-TXA group) undergoing elbow arthrolysis were included. The pooled analysis showed that TXA administration was associated with a significant reduction in total drain output (MD = \u221255.34, 95% CI: \u221280.67 to \u221230.02,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .0001) and blood loss (MD = \u221239.07, 95% CI: \u221269.71 to \u22128.43,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .01) compared to non-TXA group. Furthermore, patients treated with TXA had higher postoperative hemoglobin levels (MD = 11.73, 95% CI: 8.74 to 14.73,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .00001). No significant differences were observed in operative time, tourniquet time, or functional outcomes as measured by MEPS, VAS, or range of motion (ROM). The pooled results indicated that TXA was associated with a significant reduction in hematoma formation (RR = 0.43, 95% CI: 0.19 to 0.97,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .04) compared to the non-TXA group. However, no significant differences were found in other complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The perioperative use of tranexamic acid is an effective strategy to reduce postoperative drainage in elbow arthrolysis while preserving joint function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10225536251350423","type":"journal-article","created":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T06:35:01Z","timestamp":1749278101000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Tranexamic acid: A strategy to decrease postoperative drainage in elbow arthrolysis while preserving joint function"],"prefix":"10.1177","volume":"33","author":[{"given":"Bao","family":"Zhao","sequence":"first","affiliation":[{"name":"Shandong Provincial Hospital Affiliated to Shandong First Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlei","family":"Dong","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital Affiliated to Shandong First Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong Second Provincial General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianxin","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital Affiliated to Shandong First Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital Affiliated to Shandong First Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Lu","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital Affiliated to Shandong First Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1412-849X","authenticated-orcid":false,"given":"Fanxiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital Affiliated to Shandong First Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,7]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-024-08167-6"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-024-05220-x"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S499986"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02102-0"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003772"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06531-x"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2017.3821"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(17)30428-X"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2022.01.005"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S401968"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.177205"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S455790"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S403192"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-024-05402-7"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S320839"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2021.04.031"},{"issue":"11","key":"e_1_3_5_18_2","first-page":"1330","article-title":"[Effect of intravenous tranexamic acid on postoperative drainage and elbow joint function after traumatic elbow stiffness release]","volume":"38","author":"Meng W","year":"2024","unstructured":"Meng W, Xuan L, Li F, et al. [Effect of intravenous tranexamic acid on postoperative drainage and elbow joint function after traumatic elbow stiffness release]. Zhongguo Xiufu Chongjian Waike Zazhi 2024; 38(11): 1330\u20131335.","journal-title":"Zhongguo Xiufu Chongjian Waike Zazhi"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2023-075502"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2024.06.009"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7647"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j4008"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-019-1317-4"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-024-08012-w"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-019-05834-3"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jor.2021.03.003"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-023-06835-7"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/23259671221089608"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jse.2020.02.010"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/1758573220976055"},{"issue":"3","key":"e_1_3_5_33_2","first-page":"2278","article-title":"Effects of tranexamic acid on the postoperative hemorrhage and complications after arthrolysis for elbow stiffness","volume":"11","author":"Tang J","year":"2018","unstructured":"Tang J, Zhang Z, Li X, et al. 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