{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:20:33Z","timestamp":1788481233492,"version":"build-2803163510"},"reference-count":24,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Science and Technology Commission of Sichuan Orthopedic Hospital","award":["2021MS01"],"award-info":[{"award-number":["2021MS01"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Orthop Surg (Hong Kong)"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare osseous regeneration efficacy of allogeneic bone versus bone-induced calcium phosphate biomaterial (biological artificial material induced artificial bone, BAM-induced artificial bone) in treating tibial infected bone defects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was a prospective study that enrolled participants hospitalized at Sichuan Orthopedic Hospital for tibial osteomyelitis. These subjects had undergone osteomyelitis surgery and presented with bone defects requiring bone grafting under controlled infection conditions. Participants meeting inclusion criteria for tibial infected bone defects were divided into observation group (BAM-induced artificial bone) or control group (allogeneic bone) based on their bone graft material selection. The observation group used BAM-induced artificial bone (OICPC, Bayamon Corp) mixed with autologous iliac bone as the surgical graft material. The control group used allogeneic bone mixed with autologous iliac bone as the surgical graft material. Both materials were applied for bone defect reconstruction during surgery. Digital radiography (DR) imaging examinations were performed at three timepoints (postoperative, 3 months postoperative, 6 months postoperative) to evaluate osseous regeneration. Image J software then analyzed void ratios and absorption rates in the grafted areas. SPSS statistical analysis compared differences between the two graft materials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 56 subjects with infected bone defects were included in this study, of which 50 cases ultimately included for statistical analysis (observation group: 19 men and 7 women with a mean age of 44.12; control group: 18 men and 6 women with a mean age of 45.83). Postoperative radiographic evaluation showed varying degrees of bone absorption in both the observation group and the control group. No significant difference in void ratio was observed between the two groups immediately after surgery (observation group: 17.09 \u00b1 3.84, control group: 18.12 \u00b1 2.63;\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      = 1.101,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .277). At 3 and 6 months postoperatively, both groups demonstrated increased void ratio and absorption rate compared to the immediate postoperative values and the increase in the observation group was significantly lower than control group. At 3 months postoperatively, the void ratio and absorption rate in the observation group were significantly lower than control group (20.67 \u00b1 3.78 vs 23.56 \u00b1 4.34,\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      = 2.488,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .016; 3.58 \u00b1 2.73 vs 5.44 \u00b1 3.39,\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      = 2.118,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .039). At 6 months postoperatively, the void ratio and absorption rate in the observation group were significantly lower than control group (27.20 \u00b1 5.46 vs 31.83 \u00b1 4.71,\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      = 3.175,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .002; 10.11 \u00b1 5.25 vs 13.71 \u00b1 4.54,\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      = 2.566,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = .014); Severe absorption voids (void ratio &gt;33%) incidence in the control group (8 cases, 16%) was higher than the observation group (2 cases, 4%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BAM-induced artificial bone demonstrated superior bone-forming efficacy compared to allogeneic grafts, exhibiting significantly lower resorption rates and reduced post-grafting cavitation. Furthermore, it achieved enhanced osseous quality, optimized weight-bearing zone reconstruction, and greater functional callus formation volume relative to allogeneic bone transplantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10225536251362765","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T12:56:07Z","timestamp":1753707367000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Imaging observation of allogeneic bone and bone-induced calcium phosphate biomaterials as supplements in the treatment of infectious bone defects"],"prefix":"10.1177","volume":"33","author":[{"given":"Keye","family":"Li","sequence":"first","affiliation":[{"name":"Sichuan Orthopedic Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Yu","sequence":"additional","affiliation":[{"name":"Sichuan Orthopedic Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daqiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Sichuan Orthopedic Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sichuan Orthopedic Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Liang","sequence":"additional","affiliation":[{"name":"Sichuan Orthopedic Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"He","sequence":"additional","affiliation":[{"name":"Sichuan Orthopedic Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Guo","sequence":"additional","affiliation":[{"name":"Sichuan Orthopedic Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Tao","sequence":"additional","affiliation":[{"name":"Sichuan Orthopedic Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhong","sequence":"additional","affiliation":[{"name":"Sichuan Orthopedic Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0192-4821","authenticated-orcid":false,"given":"Zhigang","family":"Lang","sequence":"additional","affiliation":[{"name":"Sichuan Orthopedic Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"issue":"6","key":"e_1_3_5_2_2","first-page":"540","article-title":"Study progress in treatment of extremity bone defects","volume":"21","author":"Bingchuan L","year":"2019","unstructured":"Bingchuan L, Fang Z, Yun T, et al. Study progress in treatment of extremity bone defects. Chinese Journal of Orthopaedic Trauma 2019; 21(6): 540\u2013544.","journal-title":"Chinese Journal of Orthopaedic Trauma"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ksa.12342"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.2c00194"},{"key":"e_1_3_5_5_2","first-page":"30","article-title":"Curative effect of allograft mass bone grafting against calcaneal fractures","volume":"33","author":"Yong L","year":"2022","unstructured":"Yong L, Zhitao C, Ewei H, et al. Curative effect of allograft mass bone grafting against calcaneal fractures. Medical Journal of the Chinese People\u2019s Armed Police Force 2022; 33: 30\u201333.","journal-title":"Medical Journal of the Chinese People\u2019s Armed Police Force"},{"issue":"3","key":"e_1_3_5_6_2","first-page":"642","article-title":"Effect of different types of fillers on the induction of membranes by the Masquelet technique","volume":"10","author":"Yaohui L","year":"2018","unstructured":"Yaohui L, Deting X, Xiang G, et al. Effect of different types of fillers on the induction of membranes by the Masquelet technique. Chinese Journal of Orthopaedic Trauma 2018; 10(3): 642.","journal-title":"Chinese Journal of Orthopaedic Trauma"},{"key":"e_1_3_5_7_2","first-page":"594","article-title":"Casecontrol study on self setting calcium phosphate cement and allograft for Sanders II-IVfractures of calcaneus","volume":"31","author":"Wenbin X","year":"2018","unstructured":"Wenbin X, Yichun X, Hui Y, et al. Casecontrol study on self setting calcium phosphate cement and allograft for Sanders II-IVfractures of calcaneus. China J Orthop Traumatol 2018; 31: 594\u2013598.","journal-title":"China J Orthop Traumatol"},{"key":"e_1_3_5_8_2","first-page":"14","article-title":"Clinical observation on the combined surgical treatment of vancomycin and linezolid for acute osteomyelitis caused by methicillin-resistant Staphylococcus aureus","volume":"19","author":"Haifeng W","year":"2024","unstructured":"Haifeng W, Wenhua W. Clinical observation on the combined surgical treatment of vancomycin and linezolid for acute osteomyelitis caused by methicillin-resistant Staphylococcus aureus. China Prac Med 2024; 19: 14\u201318.","journal-title":"China Prac Med"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40729-021-00289-z"},{"key":"e_1_3_5_10_2","first-page":"748","article-title":"Efficacy of inactivated autologous porous bone flap and BAM bone-induced artificial bone for repairing skull defect in rats","volume":"38","author":"Chaomin W","year":"2018","unstructured":"Chaomin W, Tiejian L, Zhenhua S, et al. Efficacy of inactivated autologous porous bone flap and BAM bone-induced artificial bone for repairing skull defect in rats. J South Med Univ 2018; 38: 748\u2013754.","journal-title":"J South Med Univ"},{"key":"e_1_3_5_11_2","first-page":"1099","article-title":"BAM-induced artificial bone for the repair of benign bone tumor-like lesions","volume":"28","author":"Zhenwei T","year":"2013","unstructured":"Zhenwei T, Yimin Y, Bingang W, et al. BAM-induced artificial bone for the repair of benign bone tumor-like lesions. Chinese Journal of Bone and Joint Injury 2013; 28: 1099\u20131100.","journal-title":"Chinese Journal of Bone and Joint Injury"},{"key":"e_1_3_5_12_2","first-page":"1557","article-title":"Treatment with BAM artificial bone and autogenous marrow cells implantation after arthroscopic core decompression for ischemic necrosis of femoral head","volume":"18","author":"Kangyang L","year":"2012","unstructured":"Kangyang L, Yongxiang H, Yanling L, et al. Treatment with BAM artificial bone and autogenous marrow cells implantation after arthroscopic core decompression for ischemic necrosis of femoral head. Journal of Hainan Medical University 2012; 18: 1557\u20131559.","journal-title":"Journal of Hainan Medical University"},{"key":"e_1_3_5_13_2","first-page":"1256","article-title":"Clinical efficacy of core decompression combined with implantation of artificial BAM bone by using arhtroscopy in the treatment of ischemic necrosis of femoral head","volume":"40","author":"Gang L","year":"2015","unstructured":"Gang L. Clinical efficacy of core decompression combined with implantation of artificial BAM bone by using arhtroscopy in the treatment of ischemic necrosis of femoral head. J Guangxi Med Univ 2015; 40: 1256\u20131258.","journal-title":"J Guangxi Med Univ"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4636(200104)55:1<28::AID-JBM40>3.0.CO;2-6"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2017.03.027"},{"key":"e_1_3_5_16_2","first-page":"201806028","article-title":"Research status and progress of biomaterials for bone repair and reconstruction","volume":"32","author":"Lianfu D","year":"2018","unstructured":"Lianfu D, Feiyu Z. Research status and progress of biomaterials for bone repair and reconstruction. Chin J Reparative Reconstr Surg 2018; 32: 201806028.","journal-title":"Chin J Reparative Reconstr Surg"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbaa040"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/11\/1\/015003"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2015.11.055"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2015.11.033"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v031a02"},{"key":"e_1_3_5_22_2","first-page":"134","article-title":"Analyze the application value of DR in image imaging technology","volume":"26","author":"Jing W","year":"2020","unstructured":"Jing W. Analyze the application value of DR in image imaging technology. China Medical Device Information 2020; 26: 134\u2013136.","journal-title":"China Medical Device Information"},{"key":"e_1_3_5_23_2","first-page":"114","article-title":"Analysis of the clinical value of DR in the diagnosis of rib fractures","volume":"2","author":"Dongmei P","year":"2018","unstructured":"Dongmei P. Analysis of the clinical value of DR in the diagnosis of rib fractures. Journal of Imaging Research and Medical Applications 2018; 2: 114\u2013116.","journal-title":"Journal of Imaging Research and Medical Applications"},{"key":"e_1_3_5_24_2","first-page":"46","article-title":"Clinical application and value analysis of digital radiography (DR) image stitching technology in orthopaedics","volume":"2","author":"Hongxia C","year":"2018","unstructured":"Hongxia C, Minjun D. Clinical application and value analysis of digital radiography (DR) image stitching technology in orthopaedics. Journal of Imaging Research and Medical Applications 2018; 2: 46\u201347.","journal-title":"Journal of Imaging Research and Medical Applications"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12880-023-01046-x"}],"container-title":["Journal of Orthopaedic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10225536251362765","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10225536251362765","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10225536251362765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:32:16Z","timestamp":1777678336000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10225536251362765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1177\/10225536251362765"],"URL":"https:\/\/doi.org\/10.1177\/10225536251362765","relation":{},"ISSN":["1022-5536","2309-4990"],"issn-type":[{"value":"1022-5536","type":"print"},{"value":"2309-4990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"article-number":"10225536251362765"}}