{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:16:27Z","timestamp":1777929387919,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Chengdu Municipal Health Commission - Chengdu Medical Research Project","award":["No. 2023018"],"award-info":[{"award-number":["No. 2023018"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Orthop Surg (Hong Kong)"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the effects of denosumab on pain relief, bone mineral density (BMD), and refracture risk during long-term follow-up in patients with osteoporotic vertebral compression fractures (OVCF) after percutaneous vertebroplasty, and to identify factors associated with refracture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study included 396 OVCF patients who underwent percutaneous vertebroplasty and received denosumab between January 2021 and June 2023. Patients were classified into a completed-treatment group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 184) and a discontinued-treatment group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 212). After 1:1 propensity score matching, 101 patients were included in each group. Changes in visual analog scale (VAS) scores and lumbar spine and femoral neck T-score were compared over 24 months. Refracture risk was assessed using Kaplan\u2013Meier analysis and multivariable Cox regression in the matched cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After matching, baseline characteristics were well balanced between groups. Over 24 months of follow-up, the completed-treatment group showed significantly lower VAS scores and greater improvements in lumbar spine and femoral neck T-score compared with the discontinued-treatment group. The incidence of refracture was significantly lower in the completed-treatment group. In the PSM cohort, multivariable Cox regression analysis demonstrated that completed denosumab treatment was independently associated with a lower risk of refracture (HR = 0.314, 95% CI 0.125\u20130.792,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.014).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with OVCF treated with percutaneous vertebroplasty, persistent denosumab therapy for at least 24 months is associated with sustained pain relief, improved BMD, and a lower risk of refracture, underscoring the importance of long-term treatment adherence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10225536261417407","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:10:45Z","timestamp":1768349445000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Denosumab treatment after percutaneous vertebroplasty for osteoporotic vertebral compression fractures: Long-term follow-up of pain relief, bone mineral density changes, and risk of refracture"],"prefix":"10.1177","volume":"34","author":[{"given":"Qinglong","family":"Li","sequence":"first","affiliation":[{"name":"Sichuan Provincial Orthopedic Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huagang","family":"Shi","sequence":"additional","affiliation":[{"name":"Sichuan Provincial Orthopedic Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Chen","sequence":"additional","affiliation":[{"name":"Sichuan Provincial Orthopedic Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9109-8550","authenticated-orcid":false,"given":"Simao","family":"Song","sequence":"additional","affiliation":[{"name":"Sichuan Provincial Orthopedic Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.3906\/sag-2005-315"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-022-03038-z"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-022-00771-6"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-024-07118-0"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-91248-6"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab850"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S270829"},{"key":"e_1_3_6_9_2","first-page":"E335","article-title":"Risk factors for refracture following primary osteoporotic vertebral compression fractures","volume":"24","author":"Ji C","year":"2021","unstructured":"Ji C, Rong Y, Wang J, et al. Risk factors for refracture following primary osteoporotic vertebral compression fractures. Pain Physician 2021; 24: E335\u2013e340.","journal-title":"Pain Physician"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1179\/106698110X12595770849641"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-025-02991-z"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jbmrpl\/ziaf061"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14020329"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3427"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10010152"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2021.1369"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-018-4106-1"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.20945\/2359-3997000000560"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01936-y"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2024.07.169"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30308-5"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-021-06291-w"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-024-07139-9"}],"container-title":["Journal of Orthopaedic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10225536261417407","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10225536261417407","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10225536261417407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:33:10Z","timestamp":1777678390000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10225536261417407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/10225536261417407"],"URL":"https:\/\/doi.org\/10.1177\/10225536261417407","relation":{},"ISSN":["1022-5536","2309-4990"],"issn-type":[{"value":"1022-5536","type":"print"},{"value":"2309-4990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"article-number":"10225536261417407"}}