{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:05:00Z","timestamp":1792872300678,"version":"4.5.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Orthop Surg (Hong Kong)"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Despite systemic antibiotics and topical vancomycin powder, deep surgical-site infections (SSIs) remain a devastating complication of major posterior spine surgery, driving morbidity, costs, and antimicrobial resistance. In this study, we aimed to compare deep surgical-site infection (SSI) incidence following major posterior spine surgery between patients receiving intraoperative hypochlorous acid (HOCl) lavage and a historical control group receiving intrawound vancomycin powder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective comparative study, 161 patients undergoing major posterior spinal surgery received \u22652L of topical HOCl lavage, while 88 historical controls received intra-wound vancomycin powder. The primary endpoint was deep SSI incidence within 12\u00a0months. Demographics, operative variables, and microbiological data were analyzed with rigorous statistical methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Deep SSI rates were nearly identical: 3.1% (5\/161) with HOCl versus 3.4% (3\/88) with vancomycin (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.999), with no HOCl-related adverse effects. Pathogen profiles (including MRSA, S. epidermidis, and E. coli) were comparable between groups, underscoring HOCl\u2019s broad-spectrum efficacy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HOCl lavage showed similar deep SSI rates to intrawound vancomycin powder in this retrospective cohort; prospective multicenter studies are warranted to validate these findings and define optimal protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10225536261425277","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T06:35:12Z","timestamp":1770618912000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Hypochlorous acid lavage versus intrawound vancomycin powder for prevention of deep surgical-site infection after major posterior spine surgery: A retrospective case series with a historical control group"],"prefix":"10.1177","volume":"34","author":[{"given":"H\u0131d\u0131r","family":"\u00d6zer","sequence":"first","affiliation":[{"name":"Ordu University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeliz","family":"Ka\u015fko Arici","sequence":"additional","affiliation":[{"name":"Ordu University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sel\u00e7uk","family":"Palaoglu","sequence":"additional","affiliation":[{"name":"Acibadem Ankara Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Kutlu","sequence":"additional","affiliation":[{"name":"Acibadem Ankara Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2766-5083","authenticated-orcid":false,"given":"Vugar","family":"Nabi","sequence":"additional","affiliation":[{"name":"University of Health Science"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,8]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/BSD.0000000000000633"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/ajns.AJNS_129_19"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2016.186"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02365-22"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.31616\/asj.2018.0298"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp120568"},{"key":"e_1_3_6_8_2","first-page":"e1","article-title":"Salvage of infected orthopedic hardware with intraoperative and postoperative hypochlorous acid instillations","volume":"23","author":"Clayman E","year":"2023","unstructured":"Clayman E, Beauchamp Z, Troy J. Salvage of infected orthopedic hardware with intraoperative and postoperative hypochlorous acid instillations. Eplasty 2023; 23: e1, PMID: 36741350; PMCID: PMC9869391.","journal-title":"Eplasty"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2023.1308213"},{"key":"e_1_3_6_10_2","first-page":"S2","article-title":"Expert recommendations for the use of hypochlorous solution: science and clinical application","volume":"61","author":"Armstrong DG","year":"2015","unstructured":"Armstrong DG, Bohn G, Glat P, et al. Expert recommendations for the use of hypochlorous solution: science and clinical application. Ostomy\/Wound Manag 2015; 61: S2\u2013s19.","journal-title":"Ostomy\/Wound Manag"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2480973"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000481545"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1302\/2633-1462.44.BJO-2023-0019"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10050910"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hansur.2025.102152"}],"container-title":["Journal of Orthopaedic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10225536261425277","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10225536261425277","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10225536261425277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:33:25Z","timestamp":1777678405000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10225536261425277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/10225536261425277"],"URL":"https:\/\/doi.org\/10.1177\/10225536261425277","relation":{},"ISSN":["1022-5536","2309-4990"],"issn-type":[{"value":"1022-5536","type":"print"},{"value":"2309-4990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"article-number":"10225536261425277"}}