{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T10:23:10Z","timestamp":1779099790747,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Orthop Surg (Hong Kong)"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate hematological inflammatory indices in patients with knee osteoarthritis and to investigate their association with radiographic disease severity. It also assessed whether these indices may have adjunctive value in distinguishing early-stage from late-stage osteoarthritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 2176 patients diagnosed with knee osteoarthritis between January 1, 2023, and July 1, 2025. Patients aged 50\u201390 years with primary knee osteoarthritis and an available complete blood count (CBC) were included. Age, gender, Kellgren\u2013Lawrence (KL) stage, neutrophil, lymphocyte, monocyte, and platelet counts were recorded. Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR), systemic immune inflammation index (SII), systemic inflammation response index (SIRI), and pan-immune inflammation value (PIV) were calculated. Receiver operating characteristic (ROC) analysis and multivariable binary logistic regression adjusted for age and gender were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      NLR (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001), MLR (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001), SII (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001), SIRI (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001), and PIV (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001) were significantly higher in patients with late-stage osteoarthritis, whereas PLR did not differ significantly between groups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.061). ROC analysis showed that NLR, MLR, SII, SIRI, and PIV had statistically significant but poor to modest discriminatory ability for late-stage osteoarthritis. Although SIRI showed the highest AUC among the evaluated indices, its performance remained within the modest range, and none of the markers demonstrated clinically meaningful discriminatory ability. In multivariable binary logistic regression analysis adjusted for age and gender, NLR, MLR, SII, SIRI, and PIV remained associated after adjustment for age and gender with late-stage osteoarthritis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NLR, MLR, SII, SIRI, and PIV were associated with greater radiographic severity in knee osteoarthritis. Among the investigated biomarkers, SIRI, PIV, and SII showed relatively better discriminatory performance than the other indices; however, the overall ability of all markers to distinguish early-stage from late-stage osteoarthritis was limited. These findings suggest that CBC-derived inflammatory indices may serve as inexpensive adjunctive markers of radiographic severity, but they should not be used as stand-alone tools in clinical decision-making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10225536261449659","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:54:47Z","timestamp":1778666087000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between CBC-derived inflammatory indices and radiographic severity in knee osteoarthritis: A retrospective cohort study"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2449-9745","authenticated-orcid":false,"given":"Hakan","family":"Yola\u00e7an","sequence":"first","affiliation":[{"name":"Aksaray University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00fcseyin","family":"Erdal","sequence":"additional","affiliation":[{"name":"Aksaray University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serkan","family":"G\u00fcler","sequence":"additional","affiliation":[{"name":"Aksaray University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290816"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2005.09.007"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0036933015619588"},{"issue":"1","key":"e_1_3_5_5_2","first-page":"13","article-title":"Alternative treatment of gonarthrosis: proximal fibular osteotomy","volume":"45","author":"Gavrilovski A","year":"2024","unstructured":"Gavrilovski A, Dimovska AG, Spasov M, et al. Alternative treatment of gonarthrosis: proximal fibular osteotomy. Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2024; 45(1): 13\u201318. https:\/\/doi.org\/10.2478\/prilozi-2024-0002","journal-title":"Pril (Makedon Akad Nauk Umet Odd Med Nauki)"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20976"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2005.04.002"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2009.06.001"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.5472\/marumj.1186732"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2019.12.18"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23964"},{"issue":"8","key":"e_1_3_5_12_2","first-page":"475","article-title":"Synovial inflammation in osteoarthritis: pathogenesis and therapeutic targets","volume":"19","author":"Smith MD","year":"2023","unstructured":"Smith MD, Triantafillou S, Parker A, et al. Synovial inflammation in osteoarthritis: pathogenesis and therapeutic targets. Nat Rev Rheumatol 2023; 19(8): 475\u2013488.","journal-title":"Nat Rev Rheumatol"},{"issue":"2","key":"e_1_3_5_13_2","first-page":"85","article-title":"Osteoarthritis epidemiology and risk factors update","volume":"36","author":"Nelson AE","year":"2024","unstructured":"Nelson AE. Osteoarthritis epidemiology and risk factors update. Curr Opin Rheumatol 2024; 36(2): 85\u201392.","journal-title":"Curr Opin Rheumatol"},{"issue":"3","key":"e_1_3_5_14_2","first-page":"345","article-title":"Osteoarthritis year in review 2024: epidemiology and therapy","volume":"32","author":"Courties A","year":"2024","unstructured":"Courties A, Sellam J. Osteoarthritis year in review 2024: epidemiology and therapy. Osteoarthr Cartil 2024; 32(3): 345\u2013356.","journal-title":"Osteoarthr Cartil"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v16.i5.106145"},{"issue":"2","key":"e_1_3_5_16_2","first-page":"150","article-title":"Relationship between inflammatory markers and radiographic severity in knee osteoarthritis","volume":"39","author":"Karaman E","year":"2024","unstructured":"Karaman E, Ulusoy GR, Y\u0131lmaz S, et al. Relationship between inflammatory markers and radiographic severity in knee osteoarthritis. Arch Rheumatol. 2024; 39(2): 150\u2013158.","journal-title":"Arch Rheumatol"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3170-8"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/app10228173"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00393-017-0348-7"},{"issue":"1","key":"e_1_3_5_20_2","first-page":"55","article-title":"Association between systemic immune-inflammation index and osteoarthritis: a NHANES study","volume":"34","author":"Cheng Y","year":"2026","unstructured":"Cheng Y, Liu H, Zhang Y, et al. Association between systemic immune-inflammation index and osteoarthritis: a NHANES study. Osteoarthr Cartil 2026; 34(1): 55\u201363.","journal-title":"Osteoarthr Cartil"},{"key":"e_1_3_5_21_2","first-page":"145678","article-title":"Systemic immune-inflammation index and risk of osteoarthritis","volume":"12","author":"Chen L","year":"2025","unstructured":"Chen L, Zhang H, Li Y, et al. Systemic immune-inflammation index and risk of osteoarthritis. Front Med 2025; 12: 145678.","journal-title":"Front Med"},{"key":"e_1_3_5_22_2","first-page":"412","article-title":"Systemic inflammation response index and osteoarthritis risk","volume":"25","author":"He X","year":"2024","unstructured":"He X, Li J, Wang Y, et al. Systemic inflammation response index and osteoarthritis risk. BMC Musculoskelet Disord 2024; 25: 412.","journal-title":"BMC Musculoskelet Disord"},{"key":"e_1_3_5_23_2","first-page":"1987","article-title":"Systemic immune-inflammation index and mortality risk in osteoarthritis","volume":"24","author":"Zhou H","year":"2024","unstructured":"Zhou H, Wang Q, Li X, et al. Systemic immune-inflammation index and mortality risk in osteoarthritis. BMC Public Health 2024; 24: 1987.","journal-title":"BMC Public Health"},{"issue":"2","key":"e_1_3_5_24_2","first-page":"567","article-title":"Systemic immune-inflammation index and radiographic severity in knee osteoarthritis","volume":"44","author":"Y\u0131lmaz M","year":"2025","unstructured":"Y\u0131lmaz M, Karaman E, Demirci S, et al. Systemic immune-inflammation index and radiographic severity in knee osteoarthritis. Clin Rheumatol 2025; 44(2): 567\u2013575.","journal-title":"Clin Rheumatol"},{"issue":"6","key":"e_1_3_5_25_2","first-page":"789","article-title":"Osteoarthritis as a multifactorial disease: mechanical, metabolic, and inflammatory factors","volume":"32","author":"Perruccio AV","year":"2024","unstructured":"Perruccio AV, Power JD, Badley EM, et al. Osteoarthritis as a multifactorial disease: mechanical, metabolic, and inflammatory factors. Osteoarthr Cartil 2024; 32(6): 789\u2013798.","journal-title":"Osteoarthr Cartil"},{"issue":"5","key":"e_1_3_5_26_2","first-page":"301","article-title":"Biomarkers in osteoarthritis: current status and future perspectives","volume":"20","author":"Welhaven L","year":"2024","unstructured":"Welhaven L, Yusuf E, Haugen IK, et al. Biomarkers in osteoarthritis: current status and future perspectives. Nat Rev Rheumatol 2024; 20(5): 301\u2013315.","journal-title":"Nat Rev Rheumatol"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.5543\/tkda.2025.51336"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm15031302"}],"container-title":["Journal of Orthopaedic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10225536261449659","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10225536261449659","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10225536261449659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T09:53:25Z","timestamp":1779098005000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10225536261449659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1177\/10225536261449659"],"URL":"https:\/\/doi.org\/10.1177\/10225536261449659","relation":{},"ISSN":["1022-5536","2309-4990"],"issn-type":[{"value":"1022-5536","type":"print"},{"value":"2309-4990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"article-number":"10225536261449659"}}