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We searched PubMed, Embase, Web of Science, and Cochrane Library databases for articles that compared the clinical outcomes of patients who underwent arthroscopic or open resection of the wrist ganglion. After screening, we identified two randomized controlled trials and four retrospective comparative studies. Recurrence rates, complications, functional scores, pain, operative time, and postoperative satisfaction were analyzed. A total of 6 studies met inclusion criteria for data extraction and qualitative synthesis. The two groups had no significant differences in the recurrence rate, postoperative pain, patient satisfaction, and clinical scores. The arthroscopic group had better results than the open group in terms of time to return to work. 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Aspiration and methylprednisolone injection to the cavity with IV cannula needle in the treatment of volar wrist ganglia: new technique. 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Excision of painful dorsal wrist ganglion by open or arthroscopic approach: a comparison study. 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