{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T07:02:48Z","timestamp":1784530968103,"version":"3.55.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Orthop Surg (Hong Kong)"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To compare the real-world effectiveness and safety of denosumab versus zoledronic acid in postmenopausal osteoporosis (PMO) and characterize baseline fracture risk profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 250 PMO patients treated with denosumab (n = 148) or zoledronic acid (n = 102). Inverse probability of treatment weighting (IPTW) was applied to balance baseline covariates. The primary endpoint was 12-month change in lumbar spine bone mineral density (BMD). Fracture risk status was descriptively analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cohort was predominantly high-risk (98.4%). IPTW achieved adequate covariate balance. At 12 months, denosumab showed greater increases in lumbar spine BMD than zoledronic acid (6.09% vs. 4.82%; difference 1.27%, 95% CI: 0.474\u20132.067; P = 0.002), with consistent findings at the hip. Most adverse events were comparable between groups; however, acute phase reaction occurred significantly less frequently with denosumab, while no differences were observed in hypocalcemia or renal events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Denosumab was associated with greater BMD gains than zoledronic acid over 12 months, with broadly comparable safety in a real-world PMO population. These findings are limited to short-term BMD outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10225536261470877","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:44:23Z","timestamp":1784288663000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Real-world comparative effectiveness of denosumab versus zoledronic acid on bone mineral density changes in postmenopausal osteoporosis: An IPTW cohort study"],"prefix":"10.1177","volume":"34","author":[{"given":"Qinglong","family":"Li","sequence":"first","affiliation":[{"name":"Sichuan Provincial Orthopedic Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huagang","family":"Shi","sequence":"additional","affiliation":[{"name":"Sichuan Provincial Orthopedic Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hou","sequence":"additional","affiliation":[{"name":"Sichuan Provincial Orthopedic Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Gu","sequence":"additional","affiliation":[{"name":"Sichuan Provincial Orthopedic Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9109-8550","authenticated-orcid":false,"given":"Simao","family":"Song","sequence":"additional","affiliation":[{"name":"Sichuan Provincial Orthopedic Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp2307353"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2021.05.014"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01936-y"},{"issue":"3","key":"e_1_3_4_5_2","first-page":"1564","article-title":"Zoledronic acid and fracture risk: a meta-analysis of 12 randomized controlled trials","volume":"25","author":"He B","year":"2021","unstructured":"He B, Zhao JQ, Zhang MZ, et al. Zoledronic acid and fracture risk: a meta-analysis of 12 randomized controlled trials. Eur Rev Med Pharmacol Sci 2021; 25(3): 1564\u20131573. https:\/\/doi.org\/10.26355\/eurrev_202102_24865","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"6","key":"e_1_3_4_6_2","first-page":"545","article-title":"Denosumab in elderly osteoporotic patients. A narrative review","volume":"174","author":"Di Lorenzo L","year":"2023","unstructured":"Di Lorenzo L. Denosumab in elderly osteoporotic patients. A narrative review. Clin Ter 2023; 174(6): 545\u2013549. https:\/\/doi.org\/10.7417\/ct.2023.5023","journal-title":"Clin Ter"},{"issue":"8","key":"e_1_3_4_7_2","first-page":"1061","article-title":"Zoledronic acid for hip fracture during initial hospitalization","volume":"39","author":"Fan W","year":"2024","unstructured":"Fan W, Sun X, Leder BZ, et al. Zoledronic acid for hip fracture during initial hospitalization. J Bone Miner Res 2024; 39(8): 1061\u20131070. https:\/\/doi.org\/10.1093\/jbmr\/zjae101","journal-title":"J Bone Miner Res"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-023-04557-y"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-1801"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-014-2794-2"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-019-05176-3"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.2022.220099R1"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jbmr\/zjae068"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-025-02991-z"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3019"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2023.152304"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2021-068033"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-024-07118-0"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4804"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-021-00971-0"}],"container-title":["Journal of Orthopaedic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10225536261470877","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10225536261470877","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10225536261470877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T06:18:49Z","timestamp":1784528329000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10225536261470877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1177\/10225536261470877"],"URL":"https:\/\/doi.org\/10.1177\/10225536261470877","relation":{},"ISSN":["1022-5536","2309-4990"],"issn-type":[{"value":"1022-5536","type":"print"},{"value":"2309-4990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"article-number":"10225536261470877"}}