{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:35:57Z","timestamp":1792787757735,"version":"4.5.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Innovation & Development Medical Cooperation Program of Hengrui-Hebei","award":["HR202502048"],"award-info":[{"award-number":["HR202502048"]}]},{"name":"the Department of Finance of Hebei","award":["ZF2024132"],"award-info":[{"award-number":["ZF2024132"]}],"id":[{"id":"https:\/\/ror.org\/03106nz24","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the Department of Finance of Hebei","award":["ZF2024143"],"award-info":[{"award-number":["ZF2024143"]}],"id":[{"id":"https:\/\/ror.org\/03106nz24","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Orthop Surg (Hong Kong)"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rapid early osseointegration is essential for cementless fixation, yet this postoperative window is vulnerable in metaphyseal cancellous bone exposed to surgical injury and early loading. Salidroside, a bioactive glycoside derived from Rhodiola species, has reported osteogenic and angiogenic activity, but its value as a short-course systemic perioperative adjuvant for implant fixation remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty-eight healthy 15-week-old female C57BL\/6 mice underwent unilateral press-fit titanium implant insertion into the proximal tibia and were then randomized to intraperitoneal salidroside (20 mg\/kg every other day) or volume-matched saline. The primary outcome in this report was week-4 maximum pull-out force. Ex vivo micro-computed tomography (micro-CT) assessed five parameters in peri-implant and distal metaphyseal cancellous regions. Histology and week-2 immunostaining were supportive tissue-context assessments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At week 4, maximum pull-out force was 20.68 \u00b1 3.06 N with salidroside and 13.01 \u00b1 1.77 N with saline (mean difference, 7.67 N; Welch 95% confidence interval [CI], 3.86 to 11.48; p=0.0024). After Benjamini\u2013Hochberg false-discovery-rate correction across 11 secondary or exploratory comparisons, BV\/TV and connectivity density were higher and trabecular separation was lower in both cancellous regions (all q\u22640.05). The peri-implant trabecular-number difference was not statistically significant (p=0.0626; q=0.0861), and trabecular thickness did not differ. Week-2 HIF-1\u03b1 integrated optical density did not meet the FDR threshold in the Welch analysis (p=0.0500; q=0.0786) and was also nonsignificant in the exact Mann\u2013Whitney sensitivity analysis (p=0.1000); it was therefore treated as supportive only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In healthy 15-week-old female mice, this specific intermittent salidroside regimen increased week-4 implant fixation strength and was accompanied by concordant exploratory micro-CT findings, providing a screening-level proof-of-concept efficacy signal. The study does not establish mechanism or efficacy in male, aged, osteoporotic, or comorbidity-affected hosts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10225536261488195","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:04:59Z","timestamp":1789542299000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Short-course systemic salidroside increases week-4 tibial implant fixation strength in healthy female mice: A proof-of-concept study"],"prefix":"10.1177","volume":"34","author":[{"given":"Mengchao","family":"Liu","sequence":"first","affiliation":[{"name":"The First Hospital of Hebei Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Hospital of Hebei Medical 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