{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T21:46:05Z","timestamp":1791755165794,"version":"4.3.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Orthop Surg (Hong Kong)"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prosthetic infection is a leading cause of failure in endoprosthetic limb salvage surgery, yet comparative data between limb and pelvic reconstructions are scarce. This study characterises the microbiology, management, and outcomes of postoperative infection in this cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study of 39 patients who developed deep prosthetic infection following endoprosthetic reconstruction at a tertiary oncology centre (2007\u20132024) was conducted. Data included microbiology, surgical management, functional scores (MSTS, TESS), and survival. Descriptive comparisons were made between limb (n=32) and pelvic (n=7) reconstructions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 220 endoprosthetic replacements during the study period; the infection rate was 17.7%. With a mean follow-up of 82.5 months (range 12\u2013228), infection control was achieved in 79.5% of patients (78.1% of limbs, 85.7% of pelvic reconstructions). Two-stage revision was the most common strategy. Infections were predominantly monomicrobial (74.4%), with\n                      <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                      (33.3%) most frequent; antimicrobial-resistant organisms were present in 46.2%. Functional outcomes were superior in limb reconstructions (mean MSTS 67.0%, TESS 71.9%) versus pelvic (mean MSTS 48.7%, TESS 50.2%). The 5- and 10-year overall survival rates were 75.4% and 71.0%, respectively. Metastatic disease was an independent predictor of mortality (HR 12.59, 95% CI 1.47\u2013108.06; p=0.021).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Infection after endoprosthetic reconstruction necessitates complex management, with satisfactory control achievable in most patients. Functional outcomes are significantly poorer in pelvic reconstructions. Long-term survival is primarily determined by oncological status, particularly metastatic disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10225536261496572","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:35:44Z","timestamp":1791502544000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional outcomes, complications, and survival after endoprosthetic reconstruction for extremity tumours: A large regional cohort analysis from southeast asia"],"prefix":"10.1177","volume":"34","author":[{"given":"Kon","family":"Yuen Yi","sequence":"first","affiliation":[{"name":"University of Malaya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8899-9266","authenticated-orcid":false,"given":"Vivek","family":"Ajit Singh","sequence":"additional","affiliation":[{"name":"University Malaya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupini","family":"Devi Santharalinggam","sequence":"additional","affiliation":[{"name":"University of Malaya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6524-8451","authenticated-orcid":false,"given":"Nor Faissal","family":"Yasin","sequence":"additional","affiliation":[{"name":"University of Malaya"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-D-16-00218"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-014-0392-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-023-03553-7"},{"issue":"2","key":"e_1_3_3_5_2","first-page":"271","article-title":"Infection in orthopaedic oncology: crucial problem in modern reconstructive techniques","volume":"23","author":"Trovarelli G","year":"2019","unstructured":"Trovarelli G, Angelini A, Pala E, et al. Infection in orthopaedic oncology: crucial problem in modern reconstructive techniques. European review for medical and pharmacological sciences 2019; 23(2 Suppl): 271\u2013278. https:\/\/doi.org\/10.26355\/eurrev_201904_17501","journal-title":"European review for medical and pharmacological sciences"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60040583"},{"issue":"9","key":"e_1_3_3_7_2","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.ejso.2014.02.241","article-title":"Infective complications following tumour endoprosthesis surgery for bone and soft tissue tumours","volume":"40","author":"Peel T","year":"2014","unstructured":"Peel T, May D, Buising K, et al. Infective complications following tumour endoprosthesis surgery for bone and soft tissue tumours. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2014; 40(9): 1087\u20131094. https:\/\/doi.org\/10.1016\/j.ejso.2014.02.241","journal-title":"European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOS-D-23-01203"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2018.02.078"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.103B1.BJJ-2020-1381.R1"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis966"},{"issue":"1","key":"e_1_3_3_12_2","first-page":"87","article-title":"Surgical Site Infection in Patients Managed with an Endoprosthesis for the Treatment of Cancer: Evaluation of Patient, Disease, and Index Surgical Factors","volume":"105","author":"Ray GS","year":"2023","unstructured":"Ray GS, Werth P, Alexander JH, et al. Surgical Site Infection in Patients Managed with an Endoprosthesis for the Treatment of Cancer: Evaluation of Patient, Disease, and Index Surgical Factors. The Journal of bone and joint surgery. American volume 2023; 105(Suppl 1): 87\u201396. https:\/\/doi.org\/10.2106\/JBJS.22.01376","journal-title":"The Journal of bone and joint surgery. American volume"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.6628"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2017.02.054"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00590-020-02779-z"},{"issue":"5","key":"e_1_3_3_16_2","first-page":"418","article-title":"Failure mode classification for tumor endoprostheses: retrospective review of five institutions and a literature review","volume":"93","author":"Henderson ER","year":"2011","unstructured":"Henderson ER, Groundland JS, Pala E, et al. Failure mode classification for tumor endoprostheses: retrospective review of five institutions and a literature review. The Journal of bone and joint surgery. American volume 2011; 93(5): 418\u2013429. https:\/\/doi.org\/10.2106\/JBJS.J.00834","journal-title":"The Journal of bone and joint surgery. American volume"},{"issue":"3","key":"e_1_3_3_17_2","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00776-010-1467-z","article-title":"Postoperative deep infection in tumor endoprosthesis reconstruction around the knee","volume":"15","author":"Morii T","year":"2010","unstructured":"Morii T, Yabe H, Morioka H, et al. Postoperative deep infection in tumor endoprosthesis reconstruction around the knee. 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