{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:50:10Z","timestamp":1786647010690,"version":"build-2736575974"},"reference-count":14,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T00:00:00Z","timestamp":1442966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Australas Psychiatry"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We present a case of clozapine-related myocarditis, with a rising C-reactive protein as the only initial evidence supporting the diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>An otherwise healthy young male presenting with treatment-resistant schizophrenia was started on clozapine. Monitoring was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At day 18 he developed fever, tachycardia and a raised C-reactive protein, while troponin levels and echocardiogram remained normal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Current protocols monitoring for myocarditis have their limitations and can often only be used to support a presumptive diagnosis of myocarditis. In keeping with the current clozapine monitoring guidelines, we demonstrate that a rise in C-reactive protein levels can be a critical early sign of myocarditis warranting close monitoring and serious consideration for cessation of clozapine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1039856215604482","type":"journal-article","created":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T21:32:55Z","timestamp":1443043975000},"page":"181-184","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["C-reactive protein: an early critical sign of clozapine-related myocarditis"],"prefix":"10.1177","volume":"24","author":[{"given":"Sasha R","family":"Fehily","sequence":"first","affiliation":[{"name":"Resident Medical Officer, Department of Psychiatry, Alfred Health, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaria","family":"Forlano","sequence":"additional","affiliation":[{"name":"Consultant Psychiatrist, Department of Psychiatry, Alfred Health, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul B","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Consultant Psychiatrist, Professor of Psychiatry and Deputy Director, Department of Psychiatry, Alfred Health, Melbourne, VIC, and; Monash Alfred Psychiatry Research Centre, The Alfred and Monash University Central Clinical School, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,9,23]]},"reference":[{"key":"bibr1-1039856215604482","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.09m05024yel"},{"key":"bibr2-1039856215604482","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)10385-4"},{"key":"bibr3-1039856215604482","first-page":"1185","volume":"166","author":"Wooltorton E","year":"2002","journal-title":"Can Med Assoc J"},{"key":"bibr4-1039856215604482","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.4.4.731"},{"key":"bibr5-1039856215604482","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.2.204"},{"key":"bibr6-1039856215604482","doi-asserted-by":"publisher","DOI":"10.3109\/00048674.2011.572852"},{"key":"bibr7-1039856215604482","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.02.007"},{"key":"bibr8-1039856215604482","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.5.1703"},{"key":"bibr9-1039856215604482","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.79.933.412"},{"key":"bibr10-1039856215604482","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2014.1981"},{"key":"bibr11-1039856215604482","doi-asserted-by":"publisher","DOI":"10.1080\/j.1440-1614.2004.01481.x"},{"key":"bibr12-1039856215604482","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2011.11.022"},{"key":"bibr13-1039856215604482","doi-asserted-by":"publisher","DOI":"10.1177\/0004867412449299"},{"key":"bibr14-1039856215604482","doi-asserted-by":"publisher","DOI":"10.5830\/CVJA-2014-021"}],"container-title":["Australasian Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1039856215604482","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1039856215604482","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1039856215604482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:48:03Z","timestamp":1777376883000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1039856215604482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,23]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1177\/1039856215604482"],"URL":"https:\/\/doi.org\/10.1177\/1039856215604482","relation":{},"ISSN":["1039-8562","1440-1665"],"issn-type":[{"value":"1039-8562","type":"print"},{"value":"1440-1665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,23]]}}}