{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:13:35Z","timestamp":1792178015090,"version":"4.4.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,7,10]],"date-time":"2016-07-10T00:00:00Z","timestamp":1468108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Australas Psychiatry"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The place of monoamine oxidase inhibitors (MAOIs) in psychiatry is reviewed, and the question posed as to whether they are now justifiably disregarded by prescribers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>Multiple databases (PubMed, Medline, Embase, Cochrane) were interrogated to provide an overview regarding the use, efficacy and toxicity of MAOIs. Data regarding funded use of these agents in New Zealand were obtained from PHARMAC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Evidence supports the use of MAOIs in major depressive disorder, certain anxiety disorders and, to lesser extent, bipolar depression. Older non-selective agents, such as phenelzine and tranylcypromine, have distinctive efficacy in \u2018atypical\u2019 and treatment-resistant depression, but at the cost of serious tolerability problems. Their relegation and perception by clinicians as \u2018last resort\u2019 medications \u2013 if considered at all \u2013 has occurred in the context of various concerns, notably dietary restrictions, potential adverse drug interactions and the usual requirement for divided doses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Sufficient evidence supports consideration of MAOIs in treatment-refractory and atypical depressive disorders, and in social anxiety disorder. Psychiatrists in training need to gain experience in using these agents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1039856216634824","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T22:19:04Z","timestamp":1456438744000},"page":"371-373","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["MAOIs \u2013 does the evidence warrant their resurrection?"],"prefix":"10.1177","volume":"24","author":[{"given":"David","family":"Menkes","sequence":"first","affiliation":[{"name":"Associate Professor, Psychiatry, Waikato Clinical Campus, University of Auckland, Hamilton, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bosanac","sequence":"additional","affiliation":[{"name":"Clinical Director, Mental Health and Aged Care Services, St Vincent\u2019s Hospital, Melbourne, VIC, and; Associate Professor, Department Psychiatry, University of Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Castle","sequence":"additional","affiliation":[{"name":"Chair of Psychiatry, St Vincent\u2019s Hospital, Melbourne, VIC, and; Professor, Department Psychiatry, University of Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,10]]},"reference":[{"key":"bibr1-1039856216634824","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.11.1905"},{"key":"bibr2-1039856216634824","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa064135"},{"key":"bibr3-1039856216634824","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.10111645"},{"key":"bibr4-1039856216634824","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2012.12060751"},{"key":"bibr5-1039856216634824","doi-asserted-by":"publisher","DOI":"10.1176\/ps.50.7.945"},{"key":"bibr6-1039856216634824","doi-asserted-by":"publisher","DOI":"10.1177\/026988119000400307"},{"key":"bibr7-1039856216634824","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1176\/appi.ajp.2009.09111601","volume":"167","author":"American Psychiatric Association","year":"2010","journal-title":"Am J Psychiatry"},{"key":"bibr8-1039856216634824","doi-asserted-by":"publisher","DOI":"10.1038\/2201330a0"},{"key":"bibr9-1039856216634824","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(63)90368-4"},{"key":"bibr10-1039856216634824","volume-title":"Stahl\u2019s essential psychopharmacology: neuroscientific basic and practical applications","author":"Stahl SM.","year":"2013","edition":"4"},{"key":"bibr11-1039856216634824","first-page":"226","volume":"51","author":"Clary C","year":"1990","journal-title":"J Clin Psychiatry"},{"key":"bibr12-1039856216634824","doi-asserted-by":"publisher","DOI":"10.3109\/00048679009062902"},{"key":"bibr13-1039856216634824","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199300730-00006"},{"key":"bibr14-1039856216634824","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199652030-00013"},{"key":"bibr15-1039856216634824","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(98)00075-X"},{"key":"bibr16-1039856216634824","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurx.2005.12.007"},{"key":"bibr17-1039856216634824","first-page":"12","volume":"11","author":"Kosinksi EC","year":"2012","journal-title":"Curr Psychiatry"},{"key":"bibr18-1039856216634824","first-page":"389","volume-title":"The American Psychiatric Publishing textbook of psychopharmacology","author":"Krisnan KRR","year":"2009","edition":"4"},{"key":"bibr19-1039856216634824","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199610000-00007"},{"key":"bibr20-1039856216634824","doi-asserted-by":"publisher","DOI":"10.1097\/jcp.0b013e3181bb617"},{"key":"bibr21-1039856216634824","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aei210"},{"key":"bibr22-1039856216634824","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.148.6.705"},{"key":"bibr23-1039856216634824","unstructured":"Gillman K. 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