{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:15:41Z","timestamp":1790874941147,"version":"4.1.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T00:00:00Z","timestamp":1474848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Australas Psychiatry"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>A single case report on cannabinoid treatment for treatment-resistant Tourette syndrome (TS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>\n                      Our subject received 10.8 mg Tetrahydocannabinol and 10 mg cannabidiol daily, in the form of two oro-mucosal sprays of \u2018Sativex\n                      <jats:sup>\u00ae<\/jats:sup>\n                      \u2019, twice daily. Assessment was pre-treatment and at week one, two, and four during treatment. He completed the Yale Global Tic Severity Scale as a subjective measure, and was videoed at each stage. The videos were objectively rated by two assessors, blind to the stage of treatment, using the Original Rush Videotape Rating Scale.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Both subjective and objective measures demonstrated marked improvement in the frequency and severity of motor and vocal tics post-treatment. There was good interrater reliability of results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our results support previous research suggesting that cannabinoids are a safe and effective treatment for TS and should be considered in treatment-resistant cases. Further studies are needed to substantiate our findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1039856216663737","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T21:49:28Z","timestamp":1472075368000},"page":"541-544","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Severe motor and vocal tics controlled with Sativex\n                    <sup>\u00ae<\/sup>"],"prefix":"10.1177","volume":"24","author":[{"given":"David","family":"Trainor","sequence":"first","affiliation":[{"name":"Psychiatry Registrar, Department of Psychiatry, Tauranga Hospital, Tauranga, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois","family":"Evans","sequence":"additional","affiliation":[{"name":"Psychiatry Registrar, Department of Psychiatry, Tauranga Hospital, Tauranga, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupert","family":"Bird","sequence":"additional","affiliation":[{"name":"Consultant Psychiatrist, Department of Psychiatry, Tauranga Hospital, Tauranga, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,9,26]]},"reference":[{"key":"bibr1-1039856216663737","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.3.425"},{"key":"bibr2-1039856216663737","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-010-0118-2"},{"key":"bibr3-1039856216663737","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-011-0163-7"},{"key":"bibr4-1039856216663737","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-198812000-00021"},{"key":"bibr5-1039856216663737","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1998.tb10127.x"},{"key":"bibr6-1039856216663737","doi-asserted-by":"publisher","DOI":"10.1177\/026988119300700411"},{"key":"bibr7-1039856216663737","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1176\/ajp.156.3.495","volume":"156","author":"M\u00fcller-Vahl KR","year":"1999","journal-title":"Am J Psychiatry"},{"key":"bibr8-1039856216663737","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2011.05.033"},{"key":"bibr9-1039856216663737","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181d236ec"},{"key":"bibr10-1039856216663737","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.4.10.1717"},{"key":"bibr11-1039856216663737","first-page":"CD006565","volume":"4","author":"Curtis A","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr12-1039856216663737","doi-asserted-by":"publisher","DOI":"10.1002\/dta.1531"},{"key":"bibr13-1039856216663737","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2011.575778"},{"key":"bibr14-1039856216663737","doi-asserted-by":"publisher","DOI":"10.3109\/00207458608985678"},{"key":"bibr15-1039856216663737","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(199905)14:3<502::AID-MDS1020>3.0.CO;2-G"},{"key":"bibr16-1039856216663737","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90388-3"},{"key":"bibr17-1039856216663737","first-page":"384","volume":"28","author":"M\u00fcller-Vahl KR","year":"2003","journal-title":"Neuropharmacology"},{"key":"bibr18-1039856216663737","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)92620-1"},{"key":"bibr19-1039856216663737","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbt181"},{"key":"bibr20-1039856216663737","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61037-0"}],"container-title":["Australasian Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1039856216663737","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1039856216663737","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1039856216663737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:48:28Z","timestamp":1777376908000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1039856216663737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,26]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1177\/1039856216663737"],"URL":"https:\/\/doi.org\/10.1177\/1039856216663737","relation":{},"ISSN":["1039-8562","1440-1665"],"issn-type":[{"value":"1039-8562","type":"print"},{"value":"1440-1665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,26]]}}}