{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:35:58Z","timestamp":1783427758270,"version":"3.54.6"},"reference-count":16,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T00:00:00Z","timestamp":1507593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Australas Psychiatry"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Brexpiprazole is a new dopamine partial agonist antipsychotic in the same class as aripiprazole. This paper will briefly review brexpiprazole and compare it with aripiprazole.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Brexpiprazole and aripiprazole are both partial agonists at dopamine D\n                      <jats:sub>2<\/jats:sub>\n                      , and serotonin 5-HT\n                      <jats:sub>1A<\/jats:sub>\n                      and antagonists at serotonin 5-HT\n                      <jats:sub>2A<\/jats:sub>\n                      and noradrenergic \u03b1\n                      <jats:sub>1B<\/jats:sub>\n                      receptors. However, the two drugs are significantly different in potencies at various receptors; neurochemical profiles predict that brexpiprazole may be comparable with aripiprazole in its antipsychotic efficacy but may cause less akathisia, extrapyramidal side effects (EPS) and activation. In pivotal trials brexpiprazole demonstrated antipsychotic efficacy in short and long-term studies; it was also found to be an effective adjunct in patients with major depression resistant to antidepressants. Akathisia can occur early in treatment with brexpiprazole, as can minor weight gain and prolactin elevation. Indirect data extrapolations from pivotal studies suggest that brexpiprazole and aripiprazole have comparable efficacy but brexpiprazole may cause less akathisia. Like aripiprazole, brexpiprazole has been approved in the USA for use in schizophrenia and antidepressant-resistant depression. Although much more clinical experience is needed, brexpiprazole appears to be distinct from aripiprazole and a promising new \u2018metabolically-friendly\u2019 antipsychotic option for treatment of psychoses and mood disorders.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1039856217732473","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T02:58:12Z","timestamp":1507690692000},"page":"92-94","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Brexpiprazole: a new leaf on the partial dopamine agonist branch"],"prefix":"10.1177","volume":"26","author":[{"given":"Judy","family":"Hope","sequence":"first","affiliation":[{"name":"Senior Lecturer, Monash University, Eastern Health and Centre for Mental Health Education and Research at Delmont Private Hospital, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Castle","sequence":"additional","affiliation":[{"name":"Professor, St. Vincent\u2019s Hospital, University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas A","family":"Keks","sequence":"additional","affiliation":[{"name":"Professor, Monash University, Monash Medical Centre and Centre for Mental Health Education and Research at Delmont Private Hospital, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,10,10]]},"reference":[{"key":"bibr1-1039856217732473","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852915000954"},{"key":"bibr2-1039856217732473","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60733-3"},{"key":"bibr3-1039856217732473","doi-asserted-by":"publisher","DOI":"10.1177\/1039856216632399"},{"key":"bibr4-1039856217732473","unstructured":"Lundbeck Australia. REXULTI (Brexpiprazole) product information. 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