{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:14:56Z","timestamp":1791357296406,"version":"4.3.1"},"reference-count":11,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1037196"],"award-info":[{"award-number":["1037196"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Australas Psychiatry"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To detail some serious lamotrigine side effects and their management, and raise awareness about the possible lack of quality control of some brands of lamotrigine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A literature review is provided and some personal observations added.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>While most psychiatrists are aware of the risks of Stevens\u2013Johnson syndrome (SJS), awareness of two other serious side effects \u2013 toxic epidermal necrosis (TEN) and drug-related eosinophilia and systemic symptoms (DRESS) \u2013 is seemingly lower. Awareness that failure to respond to lamotrigine and that the prevalence of serious side effects may reflect poor quality control of some preparations is also less well recognized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>While lamotrigine may be retrialled at a lower dose escalation rate following some skin reactions, it should not be recommenced following a SJS, TEN or DRESS reaction. Prescribers should be aware of quality control concerns about some available brands of lamotrigine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1039856218760733","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T07:45:43Z","timestamp":1519631143000},"page":"640-642","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Risks associated with lamotrigine prescription: a review and personal observations"],"prefix":"10.1177","volume":"26","author":[{"given":"Gordon","family":"Parker","sequence":"first","affiliation":[{"name":"Scientia Professor of Psychiatry, University of New South Wales, Sydney, NSW, and; Professorial Fellow, Black Dog Institute, Randwick, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,2,26]]},"reference":[{"key":"bibr1-1039856218760733","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.16m11404"},{"key":"bibr2-1039856218760733","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145708009504"},{"key":"bibr3-1039856218760733","doi-asserted-by":"publisher","DOI":"10.1111\/j.1535-7511.2005.00060.x"},{"key":"bibr4-1039856218760733","volume-title":"Kaplan and Sadock\u2019s Comprehensive Textbook of Psychiatry","author":"Sadock B","year":"2005"},{"key":"bibr5-1039856218760733","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200304010-00003"},{"key":"bibr6-1039856218760733","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20175070"},{"key":"bibr7-1039856218760733","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2016.01.014"},{"key":"bibr8-1039856218760733","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680220104023"},{"key":"bibr9-1039856218760733","doi-asserted-by":"publisher","DOI":"10.1592\/phco.31.3.332"},{"key":"bibr10-1039856218760733","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.03967.x"},{"key":"bibr11-1039856218760733","first-page":"31","volume":"6","author":"Choudhary S","year":"2013","journal-title":"J Clin Aesthet Dermatol"}],"container-title":["Australasian Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1039856218760733","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1039856218760733","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1039856218760733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:49:44Z","timestamp":1777376984000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1039856218760733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,26]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1177\/1039856218760733"],"URL":"https:\/\/doi.org\/10.1177\/1039856218760733","relation":{},"ISSN":["1039-8562","1440-1665"],"issn-type":[{"value":"1039-8562","type":"print"},{"value":"1440-1665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,26]]}}}