{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:23:57Z","timestamp":1777433037214,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:00:00Z","timestamp":1593043200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Australas Psychiatry"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Sodium valproate\u2019s teratogenicity has prompted increasing restriction in its use. It is still widely prescribed to women of childbearing age in New Zealand. To examine this problem, we audited the prescribing pattern of sodium valproate in a psychiatric inpatient unit in New Zealand.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>We reviewed the clinical records of women admitted over a 2-year period (2016\u20132018). Results were analysed and compared with local and international guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Five hundred and thirty-four women of child-bearing age were admitted over the sampling period, 96 of whom (18%) were prescribed valproate on discharge. Half of these patients had diagnoses other than bipolar affective disorder, valproate\u2019s only approved psychiatric indication in New Zealand. Pregnancy testing and contraception status were documented in a minority (29 and 10 cases, respectively). Teratogenic risk discussion was documented in only 11 cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Prescription of valproate to women of childbearing age in our sample currently falls well short of best practice. Urgent action at both clinician and organisational levels is required to address this risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1039856220934317","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T20:26:36Z","timestamp":1593116796000},"page":"555-558","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Sodium valproate prescription to women of childbearing age in a New Zealand inpatient psychiatric unit"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2003-7893","authenticated-orcid":false,"given":"Rachel","family":"Goldspink","sequence":"first","affiliation":[{"name":"Waikato Hospital, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5260-0855","authenticated-orcid":false,"given":"Toni","family":"Pumipi","sequence":"additional","affiliation":[{"name":"Waikato Hospital, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7202-4085","authenticated-orcid":false,"given":"Sangeeta","family":"Dey","sequence":"additional","affiliation":[{"name":"New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3760-7896","authenticated-orcid":false,"given":"David B","family":"Menkes","sequence":"additional","affiliation":[{"name":"Waikato Hospital, New Zealand"},{"name":"Waikato Clinical Campus, University of Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,6,25]]},"reference":[{"key":"bibr1-1039856220934317","first-page":"365","volume":"27","author":"Lemperiere T.","year":"2001","journal-title":"Encephale"},{"key":"bibr2-1039856220934317","unstructured":"The Portal for Rare Diseases and Orphan Drugs. Fetal valproate Syndrome. http:\/\/www.orpha.net\/consor\/cgibin\/OC_Exp.php?Lng=GB&Expert=1906"},{"key":"bibr3-1039856220934317","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23277"},{"key":"bibr4-1039856220934317","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.4.2.345"},{"key":"bibr5-1039856220934317","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2008.04.022"},{"key":"bibr6-1039856220934317","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.176990"},{"key":"bibr7-1039856220934317","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02129.x"},{"key":"bibr8-1039856220934317","unstructured":"European Medicines Agency: valproate and related substances. https:\/\/www.ema.europa.eu\/en\/medicines\/human\/referrals\/valproate-related-substances"},{"key":"bibr9-1039856220934317","volume-title":"Antenatal and postnatal mental health: clinical management and service guidance [CG192]","author":"National Institute for Health and Care Excellence","year":"2014"},{"key":"bibr10-1039856220934317","doi-asserted-by":"publisher","DOI":"10.1177\/0004867415617657"},{"key":"bibr11-1039856220934317","first-page":"56","author":"Austin MP","year":"2017","journal-title":"Centre of Perinatal Excellence"},{"key":"bibr12-1039856220934317","unstructured":"New Zealand Medicines and Medical Devices Safety Authority. Alert communication: use of sodium valproate (Epilim) in girls and women \u2013 Change to indications and contraindications. http:\/\/www.medsafe.govt.nz\/safety\/Alerts\/Epilim.asp."},{"key":"bibr13-1039856220934317","unstructured":"Medsafe. New Zealand Medicines and Medical Devices Safety Authority. Alert communication: Use of sodium valproate (Epilim) in girls and women \u2013 Change to indications and contraindications. http:\/\/www.medsafe.govt.nz\/safety\/Alerts\/Epilim.asp."},{"key":"bibr14-1039856220934317","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.11.002"},{"key":"bibr15-1039856220934317","doi-asserted-by":"publisher","DOI":"10.1177\/1039856219828175"},{"key":"bibr16-1039856220934317","doi-asserted-by":"publisher","DOI":"10.1177\/0269881105053307"},{"key":"bibr17-1039856220934317","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12732"}],"container-title":["Australasian Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1039856220934317","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1039856220934317","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1039856220934317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:50:28Z","timestamp":1777377028000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1039856220934317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,25]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1177\/1039856220934317"],"URL":"https:\/\/doi.org\/10.1177\/1039856220934317","relation":{},"ISSN":["1039-8562","1440-1665"],"issn-type":[{"value":"1039-8562","type":"print"},{"value":"1440-1665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,25]]}}}