{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:14:24Z","timestamp":1777432464724,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Australas Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitamin D is a neuroactive hormone involved in brain development and immune regulation. It may influence psychiatric symptoms, particularly depression and schizophrenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the association between vitamin D levels and the symptoms of depression and schizophrenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The PRISMA guidelines were followed in this systematic review. A literature search was conducted in PubMed, Web of Science, Google Scholar, and Cochrane Library to identify studies published between 2014 and 2025. The studies included case-control, cohort, cross-sectional, and interventional designs that evaluated the levels of vitamin D and psychiatric symptoms in individuals with depression or schizophrenia. The risk of bias was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eleven studies met our inclusion criteria. From these results, it can be observed that there is a link between vitamin D deficiency and increased symptom severity in depression and schizophrenia. Lower vitamin D levels are related to higher severity scores of symptoms and inflammatory and neurotrophic biomarkers. However, three studies have reported no significant relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This systematic review highlights a potential association wherein vitamin D deficiency may contribute to the pathophysiology or severity of both depression and schizophrenia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10398562261430582","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:14:36Z","timestamp":1775470476000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of vitamin D deficiency in psychiatric disorders: A systematic review on association with depression and schizophrenia"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2460-9002","authenticated-orcid":false,"family":"Richa","sequence":"first","affiliation":[{"name":"Addiction psychiatry Advance trainee, Cumberland Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1009570"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.95506"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e328010ca18"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/eip.12122"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2012.07.001"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13113672"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2013.05.004"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glq185"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/17557380241265622"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.69613\/v5mv2h28"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00167"},{"key":"e_1_3_3_13_2","doi-asserted-by":"crossref","first-page":"e0165284","DOI":"10.1371\/journal.pone.0165284","article-title":"The relationship between symptom severity and low vitamin d levels in patients with schizophrenia","volume":"11","author":"Do\u011fan BS","year":"2016","unstructured":"Do\u011fan BS, Bulut S, Atalan DG, et al. The relationship between symptom severity and low vitamin d levels in patients with schizophrenia. PLoS One 2016; 11: e0165284. https:\/\/doi.org\/10.1371\/journal.pone.0165284","journal-title":"PLoS One"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s43045-020-00043-y"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-14-134"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13103343"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5507"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.11.027"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.08.031"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000580"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2018.09.024"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.12m08082"},{"key":"e_1_3_3_23_2","volume-title":"StatPearls. Treasure Island (FL)","author":"Sizar O","year":"2025","unstructured":"Sizar O, Khare S, Goyal A, et al. Vitamin d deficiency. In: StatPearls. Treasure Island (FL). StatPearls Publishing, 2025. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK532266\/ (accessed 15 February 2025)."},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01025-0"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.111.106666"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000044"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2004.08.006"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.05.014"},{"key":"e_1_3_3_30_2","unstructured":"Tangpricha V Khazai N. Vitamin d deficiency and related disorders: practice essentials background pathophysiolog. https:\/\/emedicine.medscape.com\/article\/128762-overview (2016 accessed 16 February 2025)."},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2010.12.3\/ajablensky"}],"container-title":["Australasian Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10398562261430582","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10398562261430582","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10398562261430582","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:48:35Z","timestamp":1777376915000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10398562261430582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,6]]},"references-count":30,"alternative-id":["10.1177\/10398562261430582"],"URL":"https:\/\/doi.org\/10.1177\/10398562261430582","relation":{},"ISSN":["1039-8562","1440-1665"],"issn-type":[{"value":"1039-8562","type":"print"},{"value":"1440-1665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,6]]},"article-number":"10398562261430582"}}