{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T08:02:30Z","timestamp":1781251350837,"version":"3.54.1"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Australas Psychiatry"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Post-traumatic nightmares (PTNs) are a debilitating symptom of post-traumatic stress disorder (PTSD), yet evidence for pharmacological treatment remains inconsistent. This audit examined the effectiveness and tolerability of prazosin for PTNs in an Australian inpatient psychiatric population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      A clinical audit with pre-test post-test analysis was conducted using records from Monash Health wards. Adult patients (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 50) prescribed prazosin for PTNs for \u22657 days were included. Symptom severity was measured using the Clinical Global Impression-Severity (CGI-S) scale at treatment initiation and discharge, and clinical response using the Clinical Global Impression-Improvement (CGI-I) scale. Demographics, trauma histories, comorbidities, dosing, and adverse effects were also recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participants were predominantly female (74%) and aged 18\u201334 years. The median CGI-S improved from 5 (\u201cmarkedly ill\u201d) to 2 (\u201cborderline mentally ill\u201d), representing a 3-point reduction (p &lt; .01). CGI-I ratings indicated patients were \u201cmuch improved\u201d (median = 2). Prazosin was discontinued in 12 of 114 patients, most commonly due to dizziness or hypotension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prazosin was associated with clinically and statistically significant improvements in PTNs in this cohort, noting confounding variables and subjective assessment with no control group. Findings support clinical use while underscoring the need for larger, prospective Australian trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10398562261458938","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T08:01:43Z","timestamp":1780992103000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prazosin for post-traumatic nightmares: A clinical audit in acute public psychiatric unit patients"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0659-4797","authenticated-orcid":false,"given":"Conor","family":"Heeney","sequence":"first","affiliation":[{"name":"Monash Health"},{"name":"Monash University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Rainbow","sequence":"additional","affiliation":[{"name":"Monash Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1804-5130","authenticated-orcid":false,"given":"Anton Neville","family":"Isaacs","sequence":"additional","affiliation":[{"name":"Monash University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5981-3706","authenticated-orcid":false,"given":"Nicholas A","family":"Keks","sequence":"additional","affiliation":[{"name":"Monash Health"},{"name":"Monash University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"e_1_3_7_2_2","volume-title":"National study of mental health and wellbeing [internet]","author":"Australian Bureau of Statistics","year":"2020","unstructured":"Australian Bureau of Statistics. National study of mental health and wellbeing [internet]. Canberra: ABS, 2020-2022. [cited 2025 September 14]. Available from: https:\/\/www.abs.gov.au\/statistics\/health\/mental-health\/national-study-mental-health-and-wellbeing\/latest-release"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6990"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-022-00929-x"},{"key":"e_1_3_7_5_2","volume-title":"StatPearls [Internet]","author":"Basquez R","year":"2024","unstructured":"Basquez R, Pippin MM. Prazosin. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2024. Available from. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK555959\/"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.13274"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425787"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2012.05.015"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/3527608001"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/da.20292"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.05.015"},{"key":"e_1_3_7_12_2","unstructured":"Phoenix Australia. Australian guidelines for the prevention and treatment of acute stress disorder posttraumatic stress disorder and complex PTSD. Available from: https:\/\/www.phoenixaustralia.org\/australian-guidelines-for-ptsd\/"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v61n0208"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200202000-00013"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n0705"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/0891988703256050"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.2.371"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.7205\/MILMED.170.6.513"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.09.023"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.07.001"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.06.032"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pra.0000364287.63210.92"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/jts.20570"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2011.11.010"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.12081133"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.1159\/000362243"},{"key":"e_1_3_7_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1507598"},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.7178"},{"key":"e_1_3_7_29_2","first-page":"28","article-title":"The clinical global impressions scale: applying a research tool in clinical practice","volume":"4","author":"Busner J","year":"2007","unstructured":"Busner J, Targum SD. 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