{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:27:57Z","timestamp":1791271677211,"version":"4.1.0"},"reference-count":9,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:p>After the release of a report from France on the occurrence of malformed calves genetically related to a Holstein sire, a study was performed to characterize the defect. Danish breeders were encouraged to submit defective progeny of the sire for laboratory examination. Four cases were submitted, whereas a fifth case was only reported. Lesions in affected calves were analogous, with disproportionate growth retardation characterized by fascial dysplasia and shortening of the vertebral column and the abaxial skeleton. Endochondral osteogenesis was disturbed with disorganization of epiphyseal plate chondrocytes, a lesion consistent with generalized chondrodysplasia. Based on morphology, the defect was grouped as a \u201cDexter bulldog type\u201d. A genetic etiology was suspected as cases occurred in a familial pattern. Genealogical evaluation revealed several common ancestors belonging to widely used breeding lines of US Holstein, but because of the extensive use of these sires, their presence in the pedigrees of affected calves might be accidental. Further studies are needed to determine the mode of inheritance.<\/jats:p>","DOI":"10.1177\/104063870401600406","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T16:26:52Z","timestamp":1305217612000},"page":"293-298","source":"Crossref","is-referenced-by-count":23,"title":["Familial Chondrodysplasia in Holstein Calves"],"prefix":"10.1177","volume":"16","author":[{"given":"Jorgen S.","family":"Agerholm","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Pathology, Department of Pharmacology and Pathobiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Arnbjerg","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Radiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Andersen","sequence":"additional","affiliation":[{"name":"Royal Veterinary and Agricultural University, B\u00fclowsvej 17, DK-1870 Frederiksberg C, Denmark, and Danish Cattle, Udkaersvej 15, Skejby, DK-8200 Aarhus N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2004,7,1]]},"reference":[{"key":"bibr1-104063870401600406","doi-asserted-by":"publisher","DOI":"10.1177\/104063870101300401"},{"key":"bibr2-104063870401600406","first-page":"57","volume":"60","author":"Berger J","year":"1948","journal-title":"Vet Rec"},{"key":"bibr3-104063870401600406","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1923.0035"},{"key":"bibr4-104063870401600406","first-page":"1","volume":"80","author":"Gotink WM","year":"1955","journal-title":"Tijdschr Diergeneeskd"},{"key":"bibr5-104063870401600406","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.1974.tb01339.x"},{"key":"bibr6-104063870401600406","unstructured":"Huston K, Saperstein G, Steffen D, 2000, Clinical, pathological and other visible traits loci except coat colour. In: Mendelian inheritance in cattle 2000, ed. Millar P, Lauvergne JJ, Dolling C, pp. 243\u2013262. EAAP Publication No. 101. Wageningen Pers, Wageningen, The Netherlands."},{"key":"bibr7-104063870401600406","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.1987.tb00270.x"},{"key":"bibr8-104063870401600406","doi-asserted-by":"publisher","DOI":"10.1136\/vr.102.18.404-a"},{"key":"bibr9-104063870401600406","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700090306"}],"container-title":["Journal of Veterinary Diagnostic Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/104063870401600406","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/104063870401600406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:09:31Z","timestamp":1777680571000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/104063870401600406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["10.1177\/104063870401600406"],"URL":"https:\/\/doi.org\/10.1177\/104063870401600406","relation":{},"ISSN":["1040-6387","1943-4936"],"issn-type":[{"value":"1040-6387","type":"print"},{"value":"1943-4936","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}