{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:35:12Z","timestamp":1784039712642,"version":"3.55.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:p>Three outbreaks of late-gestation abortions in does and ulcerative posthitis in bucks, associated with caprine herpes virus\u20131 (CHV-1), in California are described. In herd A, 10 of 17 does aborted in a 7-day period, whereas in herd B, 4 of 130 does aborted in a 45-day period and in herd C, 100 of 300 does aborted in a 3-week period. Most fetuses had multifocal pinpoint depressed foci with a zone of hyperemia on external and cut surfaces of the kidneys, liver, lungs, and adrenal glands. Histologically, scattered multifocal areas of necrosis with mild neutrophilic infiltrate were observed in kidneys, brain, liver, adrenal glands, and lungs of most fetuses of the 3 herds. Large amphophilic intranuclear inclusion bodies, which displaced the chromatin, were observed in cells within and around the necrotic foci in kidneys and adrenal glands. Particles 85\u2013113 nm in size with morphology compatible with herpes virus were observed in the nuclei of these cells when examined by electron microscopy. Irregular, shallow, red ulcers were observed in the prepuce of 1 buck from herd C. Prepuce biopsies from this animal had necrosis of the superficial mucosal epithelium and severe submucosal lymphoplasmocytic infiltrates. Large intranuclear amphophilic inclusion bodies were observed in most cells of the stratum spinosum of the preputial epithelium, but no viral particles were observed in these cells. Caprine herpes virus\u20131 was isolated from tissue pools of fetuses from the 3 herds but not from prepuce biopsies. Positive results were obtained when tissues of a fetus from herd C were processed by a polymerase chain reaction technique to amplify the amino terminus of the glycoprotein C gene of CHV-1. Sera from aborted does from herds B and C and from the 3 bucks from herd C had high antibody titers to CHV-1. The results presented here support the hypothesis that the male goat is involved in the transmission of CHV-1. However, other forms of transmission cannot be ruled out.<\/jats:p>","DOI":"10.1177\/104063870401600523","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T16:26:52Z","timestamp":1305217612000},"page":"478-484","source":"Crossref","is-referenced-by-count":34,"title":["Abortion and Ulcerative Posthitis Associated with Caprine Herpesvirus\u20131 Infection in Goats in California"],"prefix":"10.1177","volume":"16","author":[{"given":"Francisco A.","family":"Uzal","sequence":"first","affiliation":[{"name":"California Animal Health and Food Safety Laboratory System, San Bernardino Branch, School of Veterinary Medicine, University of California, Davis, 105 West Central Avenue, San Bernardino, CA 92408"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Woods","sequence":"additional","affiliation":[{"name":"The California Animal Health and Food Safety Laboratory System, Davis Branch, University of California Davis, CA 95617"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Stillian","sequence":"additional","affiliation":[{"name":"The California Animal Health and Food Safety Laboratory System, Davis Branch, University of California Davis, CA 95617"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Nordhausen","sequence":"additional","affiliation":[{"name":"The California Animal Health and Food Safety Laboratory System, Davis Branch, University of California Davis, CA 95617"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deryck H.","family":"Read","sequence":"additional","affiliation":[{"name":"California Animal Health and Food Safety Laboratory System, San Bernardino Branch, School of Veterinary Medicine, University of California, Davis, 105 West Central Avenue, San Bernardino, CA 92408"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Van Kampen","sequence":"additional","affiliation":[{"name":"Veterinary Diagnostic Laboratory, Colorado State University, CO 80523"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenee","family":"Odani","sequence":"additional","affiliation":[{"name":"California Animal Health and Food Safety Laboratory System, San Bernardino Branch, School of Veterinary Medicine, University of California, Davis, 105 West Central Avenue, San Bernardino, CA 92408"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Hietala","sequence":"additional","affiliation":[{"name":"The California Animal Health and Food Safety Laboratory System, Davis Branch, University of California Davis, CA 95617"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. J.","family":"Hurley","sequence":"additional","affiliation":[{"name":"California Animal Health and Food Safety Laboratory System, San Bernardino Branch, School of Veterinary Medicine, University of California, Davis, 105 West Central Avenue, San Bernardino, CA 92408"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary L.","family":"Vickers","sequence":"additional","affiliation":[{"name":"The Livestock Disease Diagnostic Center, University of Kentucky, KY 40511."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon M.","family":"Gard","sequence":"additional","affiliation":[{"name":"California Animal Health and Food Safety Laboratory System, San Bernardino Branch, School of Veterinary Medicine, University of California, Davis, 105 West Central Avenue, San Bernardino, CA 92408"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2004,9,1]]},"reference":[{"key":"bibr1-104063870401600523","first-page":"1763","volume":"36","author":"Berrios PE","year":"1975","journal-title":"Am J Vet Res"},{"key":"bibr2-104063870401600523","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1.1.46"},{"key":"bibr3-104063870401600523","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1986.tb02935.x"},{"key":"bibr4-104063870401600523","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.1982.34919"},{"key":"bibr5-104063870401600523","doi-asserted-by":"publisher","DOI":"10.1159\/000163999"},{"key":"bibr6-104063870401600523","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4800(03)00038-8"},{"key":"bibr7-104063870401600523","doi-asserted-by":"publisher","DOI":"10.1177\/104063870101300317"},{"key":"bibr8-104063870401600523","first-page":"879","volume":"160","author":"Mohanty SB","year":"1972","journal-title":"J Am Vet Med Assoc"},{"key":"bibr9-104063870401600523","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.1999.0375"},{"key":"bibr10-104063870401600523","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(99)00103-2"},{"key":"bibr11-104063870401600523","first-page":"847","volume":"35","author":"Saito JK","year":"1974","journal-title":"Am J Vet Res"},{"key":"bibr12-104063870401600523","first-page":"605","volume":"40","author":"Saxegaard F","year":"1970","journal-title":"Vet Bull"},{"key":"bibr13-104063870401600523","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1987.tb07345.x"},{"key":"bibr14-104063870401600523","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199602)178:2<221::AID-PATH441>3.0.CO;2-W"},{"key":"bibr15-104063870401600523","unstructured":"Uzal FA, McFarland M, Woolcock P, 2003, Diagnostic associations between gross lesions and virus isolation during the 2002\u20132003 Newcastle disease outbreak in California. 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