{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:15:36Z","timestamp":1790021736990,"version":"4.0.1"},"reference-count":20,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:p>Within the framework of the active surveillance for transmissible spongiform encephalopathies in sheep in Sweden, 4 cases of the atypical form of scrapie, Nor98, were identified during 2003. Nor98 is a recently recognized and poorly understood variant of scrapie, first described in Norway. The cases were positive by the rapid test (enzyme-linked immunosorbent assay). Immunohistochemical staining showed diffuse thin-granular staining of the cerebellar cortex. Western immunoblotting analysis of specimens of brain stem and cerebellum showed a light band of approximately 12 kDa. Typical scrapie was ruled out based on the confirmatory testing. The affected ewes were from 4 different flocks. They were between 7 and 9 years old. Two were of the ARQ\/ARQ genotype, 1 ARR\/ARQ, and 1 ARR\/AHQ. Two ewes had shown ataxia, and the other 2 had no clinical signs. Whole-flock slaughter was applied, and testing of the flock mates did not reveal additional cases. Nor98 differs from typical scrapie in its epidemiology, frequency of genotypes of sheep affected, clinical signs, microscopic lesions, distribution of scrapie prion protein in the brain, and characteristics of the immunostaining and immunoblotting profiles.<\/jats:p>","DOI":"10.1177\/104063870401600611","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T16:26:52Z","timestamp":1305217612000},"page":"562-567","source":"Crossref","is-referenced-by-count":67,"title":["Recognition of the Nor98 Variant of Scrapie in the Swedish Sheep Population"],"prefix":"10.1177","volume":"16","author":[{"given":"D.","family":"Gavier-Wid\u00e9n","sequence":"first","affiliation":[{"name":"National Veterinary Institute (SVA), Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"N\u00f6remark","sequence":"additional","affiliation":[{"name":"National Veterinary Institute (SVA), Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Benestad","sequence":"additional","affiliation":[{"name":"National Veterinary Institute, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Simmons","sequence":"additional","affiliation":[{"name":"Veterinary Laboratory Agency, Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Renstr\u00f6m","sequence":"additional","affiliation":[{"name":"National Veterinary Institute (SVA), Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Bratberg","sequence":"additional","affiliation":[{"name":"National Veterinary Institute, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Elvander","sequence":"additional","affiliation":[{"name":"National Veterinary Institute (SVA), Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.H\u00e5rd af","family":"Segerstad","sequence":"additional","affiliation":[{"name":"National Veterinary Institute (SVA), Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2004,11,1]]},"reference":[{"key":"bibr1-104063870401600611","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.2002.0558"},{"key":"bibr2-104063870401600611","doi-asserted-by":"publisher","DOI":"10.1136\/vr.153.7.202"},{"key":"bibr3-104063870401600611","unstructured":"Benestad SL, Ledur A, 2004, Efficient propagation of Nor98 scrapie agent in transgenic mice. First International Conference of the European Network of Excellence NeuroPrion."},{"key":"bibr4-104063870401600611","doi-asserted-by":"publisher","DOI":"10.1038\/39057"},{"key":"bibr5-104063870401600611","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-76-8-2097"},{"key":"bibr6-104063870401600611","doi-asserted-by":"publisher","DOI":"10.1186\/BF03548650"},{"key":"bibr7-104063870401600611","unstructured":"European Parliament and the Council of the European Union. Regulation (EC) No 999\/2001: 2003, Rules for the prevention, control and eradication of certain transmissible spongiform encephalopathies. 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