{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:32:27Z","timestamp":1777930347627,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:p>Cattle in western Uruguay that were eating Solanum bonariense developed periodic episodes of ataxia, hypermetria, hyperesthesia, head and thoracic limb extension, opisthotonus, nystagmus, and falling to the side or backward. Similar clinical signs were experimentally reproduced in cattle by administration of S. bonariense via rumen cannula at a dose of 1,024 g\/kg body mass. No significant gross lesions were observed in field cases or experimentally induced cases. Spontaneous and induced histologic lesions were similar and included vacuolation, degeneration, and loss of Purkinje cells. Axonal spheroids, microcavitations, and other changes of wallerian-type degeneration in cerebellar white matter were also observed. Ultrastructural changes included increased number of electron-dense residual storage bodies in membrane-bound vesicles in affected Purkinje cells, and similar vesicles and mitochondria in axonal spheroids. No histologic lesions were detected in the other examined tissues. The Purkinje-cell swelling and vacuolation with subsequent cerebellar degeneration are suggestive of Purkinje-cell specific toxin that produces abnormal lysosome function and cell specific axonal transport. This is the first report of S. bonariense toxicity.<\/jats:p>","DOI":"10.1177\/104063870601800314","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T16:26:52Z","timestamp":1305217612000},"page":"299-303","source":"Crossref","is-referenced-by-count":21,"title":["Cerebellar Degeneration in Cattle Grazing\n                    <i>Solanum Bonariense<\/i>\n                    (\u201cNaranjillo\u201d) in Western Uruguay"],"prefix":"10.1177","volume":"18","author":[{"given":"Jos\u00e9 Manuel","family":"Verdes","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Biology, Veterinary Faculty, Universidad de la Rep\u00fablica Oriental del Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Mora\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Pathology, Veterinary Faculty, Universidad de la Rep\u00fablica Oriental del Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Veterinary Faculty, Universidad de la Rep\u00fablica Oriental del Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Battes","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Veterinary Faculty, Universidad de la Rep\u00fablica Oriental del Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Eusebio","family":"Fidalgo","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Veterinary Faculty, Universidade de Santiago de Compostela, Lugo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florentina","family":"Guerrero","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Animal Production, Veterinary Faculty, Universidade de Santiago de Compostela, Lugo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2006,5,1]]},"reference":[{"key":"bibr1-104063870601800314","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1997.tb15719.x"},{"key":"bibr2-104063870601800314","first-page":"447","volume-title":"Plantas t\u00f3xicas: Vegetales peligrosos para el hombre y los animales","author":"Bruneton J","year":"2001"},{"key":"bibr3-104063870601800314","doi-asserted-by":"publisher","DOI":"10.1177\/104063879901100310"},{"key":"bibr4-104063870601800314","first-page":"1","volume":"7","author":"de Barros SS","year":"1987","journal-title":"Pesq Vet Bras"},{"key":"bibr5-104063870601800314","unstructured":"Linnaeus C: 1753, Solanum bonariense. 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