{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:34:10Z","timestamp":1777930450628,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p>The current study was designed to determine the changes of the cardiac troponin I (cTnI) expression in blood and tissue during the myocardial degeneration in calves with foot-and-mouth disease (FMD). Seventeen crossbred calves presenting pathological signs for FMD confirmed by viral analysis were studied. A biochemistry panel and immunohistochemistry were performed on 17 diseased calves and 7 calves used as controls. Creatine kinase (CK), CK-myocardial band (CK-MB), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) activities were analyzed for both groups. Cardiac troponin I levels were measured by a commercially available enzyme-linked immunosorbent assay kit. Mean cTnI (14.8 \u00b1 1.9 ng\/ml) concentration and CK (573 \u00b1 407 U\/l), CK-MB (238 \u00b1 37 U\/l), AST (84 \u00b1 7), and LDH (298 \u00b1 29 U\/l) activities were higher in FMD cases compared with controls. Immunohistochemistry revealed loss or depletion of cTnI expression in myocardium of all cases. None of the 7 controls showed loss of cTnI expression. Increased serum cTnI concentration correlated with myocardial injury and loss of cTnI immunolabeling in cardiomyocytes of calves with FMD.<\/jats:p>","DOI":"10.1177\/104063870802000510","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T16:26:52Z","timestamp":1305217612000},"page":"598-605","source":"Crossref","is-referenced-by-count":29,"title":["Determination of Cardiac Troponin I in the Blood and Heart of Calves with Foot-and-Mouth Disease"],"prefix":"10.1177","volume":"20","author":[{"given":"Recai","family":"Tunca","sequence":"first","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, University of Adnan Menderes, Aydin, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmut","family":"Sozmen","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Faculty of Veterinary Medicine, Kafkas University, Kars, 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