{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:33:49Z","timestamp":1777930429840,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:p>Acute and, particularly, chronic copper exposures, along with defects in hepatic copper metabolism, altered excretion of copper, and\/or nutritional imbalances between copper and other trace elements, can lead to hepatic accumulation of copper and primary copper toxicosis. There is interspecies variation in susceptibility to copper toxicosis, with sheep being the species most likely to develop this condition. Adult dairy goats and Boer crosses are generally considered resistant to chronic copper toxicosis, especially the hemolytic stage of this disease. The current report is rather unusual in that it describes instances of naturally occurring copper toxicosis with hemolysis and hemoglobinuric nephrosis in 3 adult Boer goats. In 2 of these goats, a possible source of excessive dietary copper was investigated but not definitively identified. In the third goat, the etiologic factors associated with the copper toxicosis were not determined. It appears that mature Boer goats are susceptible to the hemolytic stage of chronic copper toxicosis, which was not observed in a recent, large-scale copper intoxication involving lactating dairy goats. Copper analyses on both liver and kidney samples were necessary to confirm the diagnosis of copper toxicosis in all 3 goats. All feedstuffs associated with instances of copper toxicosis should be analyzed for iron, molybdenum, sulphur, and zinc as well as copper to determine what nutritional factors are contributing to the pathogenesis of this disease. Consideration also should be given to the ingestion of hepatotoxic plants and other toxic exposures, which could predispose an animal to secondary chronic copper toxicosis.<\/jats:p>","DOI":"10.1177\/104063870902100319","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T16:29:05Z","timestamp":1305217745000},"page":"395-400","source":"Crossref","is-referenced-by-count":26,"title":["Copper Toxicosis with Hemolysis and Hemoglobinuric Nephrosis in Three Adult Boer Goats"],"prefix":"10.1177","volume":"21","author":[{"given":"Chantelle C.","family":"Bozynski","sequence":"first","affiliation":[{"name":"Department of Veterinary Medical Diagnostic Laboratory, Columbia, MO."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim J.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Diagnostic Laboratory, Columbia, MO."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young 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