{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:34:12Z","timestamp":1777930452025,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:p>An undifferentiated renal tubular carcinoma was diagnosed in a juvenile male olive baboon (Papio anubis). The animal suddenly appeared depressed and refused to eat. During physical examination, a firm, palpable mass in the left abdominal area and flank pain were detected. Clinical pathology findings included mild anemia, hypoalbuminemia, hyponatremia, and mildly increased serum creatinine and urea concentrations. Radiographs revealed a large mass in the left abdominal area. Exploratory laparotomy disclosed a 10 cm \u00d7 15 cm multilobulated mass involving the left kidney and adjacent organs. Because of a poor prognosis, the animal was humanely euthanized, and necropsy was performed. Tissue samples of the neoplasm were taken for histopathological examination. Immunohistochemical staining was done using vimentin, cytokeratin, S-100 protein, Ki-67, \u03b1-actin, and desmin-specific primary antibodies. Microscopically, elongated and irregular tubules were lined by 2 or more layers of atypical epithelial cells. Anisocytosis, anisokaryosis, and frequent mitotic figures were also observed. Following immunohistochemical staining, the cytoplasm of neoplastic cells was positive for cytokeratin, vimentin, and S-100 protein and negative for \u03b1-actin and desmin. Positive nuclear staining for Ki-67 was observed. The neoplasm was diagnosed as an undifferentiated renal tubular carcinoma.<\/jats:p>","DOI":"10.1177\/104063870902100419","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T16:29:05Z","timestamp":1305217745000},"page":"535-539","source":"Crossref","is-referenced-by-count":2,"title":["Clinical, Histologic, and Immunohistochemical Features of an Undifferentiated Renal Tubular Carcinoma in a Juvenile Olive Baboon\n                    <i>(Papio anubis)<\/i>"],"prefix":"10.1177","volume":"21","author":[{"given":"Nuria","family":"Garc\u00eda","sequence":"first","affiliation":[{"name":"Departments of Animal Production"},{"name":"University of Murcia, Murcia, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Ramis","sequence":"additional","affiliation":[{"name":"Departments of Animal Production"},{"name":"University of Murcia, Murcia, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco 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