{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:20:25Z","timestamp":1777944025020,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p>\n                    Gangliogliomas are composed of neoplastic glial and neuronal cells and are extremely rare tumors of the central nervous system of domestic animals. The present report describes the clinical presentation and the pathomorphological and immunophenotypical characteristics of a desmoplastic ganglioglioma in the spinal cord of a 3-year-old male western European hedgehog (\n                    <jats:italic toggle=\"yes\">Erinaceus europaeus<\/jats:italic>\n                    ). Clinically, the hedgehog exhibited a skin wound and therapy-resistant paresis of the left hind limb. Necropsy showed dilatation of the urinary bladder. Histologic examination of the thoracic spinal cord revealed a focally extensive infiltrative mass, which consisted of multiple nodules of smaller bipolar or oligopolar glial cells and variably sized polygonal, ganglionic, neuron-like cells embedded in variable amounts of microcystic neuropilic matrix. An area of spindle-shaped cells arranged in interwoven fascicles and surrounded by a prominent network of reticulin fibers was interpreted as desmoplastic leptomeningeal stroma. Immunohistochemistry revealed a moderate number of glial fibrillary acidic protein and S-100-positive cells and processes. In addition, the ganglionic neuron-like cells expressed neurofilament, microtubule-associated protein-2, and neuron-specific enolase. In summary, this spinal cord tumor was composed of astroglial and neuronal cellular elements, justifying the diagnosis of a desmoplastic ganglioglioma.\n                  <\/jats:p>","DOI":"10.1177\/104063871002200623","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T16:29:05Z","timestamp":1305217745000},"page":"978-983","source":"Crossref","is-referenced-by-count":10,"title":["Desmoplastic Ganglioglioma of the Spinal Cord in a Western European Hedgehog (\n                    <i>Erinaceus Europaeus<\/i>\n                    )"],"prefix":"10.1177","volume":"22","author":[{"given":"Reiner","family":"Ulrich","sequence":"first","affiliation":[{"name":"Departments of Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra C.","family":"Stan","sequence":"additional","affiliation":[{"name":"University of Veterinary Medicine Hannover, Hannover, Germany; and the Institute of Neuropathology, Evangelisches Krankenhaus Bielefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Fehr","sequence":"additional","affiliation":[{"name":"Small Animal Medicine and Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolin","family":"Mallig","sequence":"additional","affiliation":[{"name":"Small Animal Medicine and Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Puff","sequence":"additional","affiliation":[{"name":"Departments of Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,11]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/96.5.669"},{"key":"e_1_3_2_3_2","first-page":"103","volume-title":"World Health Organization classification of tumors of the central nervous system","author":"Becker AJ","year":"2007","unstructured":"Becker AJ, Wiestler OD, Figarella-Branger D, Bl\u00fcmcke I: 2007, Ganglioglioma and gangliocytoma. In: World Health Organization classification of tumors of the central nervous system, ed. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, 4th ed., pp. 103\u2013105. WHO Press, Geneva, Switzerland.","edition":"4"},{"key":"e_1_3_2_4_2","first-page":"96","volume-title":"World Health Organization classification of tumors of the central nervous system","author":"Brat DJ","year":"2007","unstructured":"Brat DJ, Vandenberg SR, Figarella-Branger D, Taratuto AL: 2007, Desmoplastic infantile astrocytoma and ganglioglioma. In: World Health Organization classification of tumors of the central nervous system, ed. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, 4th ed., pp. 96\u201398. 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