{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:34:10Z","timestamp":1791120850520,"version":"4.1.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2011,12,6]],"date-time":"2011-12-06T00:00:00Z","timestamp":1323129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>A retrospective study was performed to compare the treatment regimens in feedlot cattle that died with bovine respiratory disease (BRD) to the antimicrobial susceptibility patterns of the microorganisms isolated from lungs. Forty-three cattle submitted by the Willard Sparks Beef Research Center (WSBRC) to the Oklahoma Animal Disease Diagnostic Laboratory for postmortem examination during 2007 had bronchopneumonia (acute = 16, subacute = 5, or chronic = 22). Lungs from cattle were cultured aerobically (40 cattle) and for Mycoplasma spp. (34 cattle). Susceptibility panels were performed. At least 1 BRD pathogen ( Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, Mycoplasma bovis, or Arcanobacterium pyogenes) was isolated from 39 cattle, and 77% (30\/39) had multiple organisms recovered. Mycoplasmal infections were common (25\/34) and a major component of mixed infections (24\/25). The majority (60%) of the M. haemolytica, P. multocida, and H. somni isolates were resistant to tetracycline. Most of the H. somni isolates (67%) were susceptible to tilmicosin (Ti), enrofloxacin (En), ceftiofur (Ce), and florfenicol, despite extensive treatment with Ti, En, and Ce (75% of isolates were from cattle that received each antimicrobial once). Most of the M. haemolytica (65%) and P. multocida (79%) isolates were susceptible to En and Ce, despite antemortem treatment of cattle with these antimicrobials. Hence, the current study reports a discrepancy between the antemortem treatment of clinical BRD and the susceptibility patterns of the bacteria isolated from lungs postmortem. Based on these findings, factors other than antimicrobial resistance are playing a role in the death of feedlot cattle with BRD.<\/jats:p>","DOI":"10.1177\/1040638711428149","type":"journal-article","created":{"date-parts":[[2011,12,7]],"date-time":"2011-12-07T00:40:07Z","timestamp":1323218407000},"page":"277-282","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Comparison of antemortem antimicrobial treatment regimens to antimicrobial susceptibility patterns of postmortem lung isolates from feedlot cattle with bronchopneumonia"],"prefix":"10.1177","volume":"24","author":[{"given":"Catherine G.","family":"Lamm","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine, University of Glasgow, Glasgow, UK (Lamm)"},{"name":"Oklahoma Animal Disease Diagnostic Laboratory (Love), Oklahoma State University, Stillwater, OK"},{"name":"Department of Animal Science (Krehbiel), Oklahoma State University, Stillwater, OK"},{"name":"Center for Veterinary Health Sciences (Johnson, Step), Oklahoma State University, Stillwater, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda C.","family":"Love","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Glasgow, Glasgow, UK (Lamm)"},{"name":"Oklahoma Animal Disease Diagnostic Laboratory (Love), Oklahoma State University, Stillwater, OK"},{"name":"Department of Animal Science (Krehbiel), Oklahoma State University, Stillwater, OK"},{"name":"Center for Veterinary Health Sciences (Johnson, Step), Oklahoma State University, Stillwater, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clint R.","family":"Krehbiel","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Glasgow, Glasgow, UK (Lamm)"},{"name":"Oklahoma Animal Disease Diagnostic Laboratory (Love), Oklahoma State University, Stillwater, OK"},{"name":"Department of Animal Science (Krehbiel), Oklahoma State University, Stillwater, OK"},{"name":"Center for Veterinary Health Sciences (Johnson, Step), Oklahoma State University, Stillwater, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Johnson","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Glasgow, Glasgow, UK (Lamm)"},{"name":"Oklahoma Animal Disease Diagnostic Laboratory (Love), Oklahoma State University, Stillwater, OK"},{"name":"Department of Animal Science (Krehbiel), Oklahoma State University, Stillwater, OK"},{"name":"Center for Veterinary Health Sciences (Johnson, Step), Oklahoma State University, Stillwater, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas L.","family":"Step","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Glasgow, Glasgow, UK (Lamm)"},{"name":"Oklahoma Animal Disease Diagnostic Laboratory (Love), Oklahoma State University, Stillwater, OK"},{"name":"Department of Animal Science (Krehbiel), Oklahoma State University, Stillwater, OK"},{"name":"Center for Veterinary Health Sciences (Johnson, Step), Oklahoma State University, Stillwater, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,12,6]]},"reference":[{"key":"bibr1-1040638711428149","first-page":"281","volume":"56","author":"Allen JW","year":"1992","journal-title":"Can J Vet Res"},{"key":"bibr2-1040638711428149","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0720(15)30314-5"},{"key":"bibr3-1040638711428149","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvfa.2006.03.009"},{"key":"bibr4-1040638711428149","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0720(03)00057-4"},{"key":"bibr5-1040638711428149","first-page":"473","volume":"49","author":"Booker CW","year":"2008","journal-title":"Can Vet J"},{"key":"bibr6-1040638711428149","doi-asserted-by":"publisher","DOI":"10.1017\/S1466252308001515"},{"key":"bibr7-1040638711428149","unstructured":"Clinical and Laboratory Standards Institute (CLSI): 2008, Performance standards for antimicrobial disk and dilution susceptibility tests for bacteria isolated from animals; approved standard\u2014third edition. 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