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In the current study, alopecia, severe epidermal and follicular orthokeratosis, and acanthosis due to hypovitaminosis A are reported in 2 of 32 Angus calves, with a third animal suspected. Affected animals responded to vitamin A supplementation, and no additional calves displayed signs. Vitamin A acts on skin by regulating DNA transcription in keratinocytes, reducing the number of tonofilaments and desmosomes, both involved in cell-to-cell adhesion. Hence, adequate levels of dietary vitamin A are necessary for normal keratinocyte turnover, and deficiencies result in retention of keratinized cells (orthokeratosis). The present report reminds diagnosticians to consider vitamin A deficiency in cases of orthokeratotic dermatopathy in cattle.<\/jats:p>","DOI":"10.1177\/1040638712445767","type":"journal-article","created":{"date-parts":[[2012,5,15]],"date-time":"2012-05-15T01:42:14Z","timestamp":1337046134000},"page":"763-766","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Dermatopathy in juvenile Angus cattle due to vitamin A deficiency"],"prefix":"10.1177","volume":"24","author":[{"given":"Thomas J.","family":"Baldwin","sequence":"first","affiliation":[{"name":"Utah Veterinary Diagnostic Laboratory, Logan, UT (Baldwin, Kelly, Hall)"},{"name":"Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT (Baldwin, Rood, Kelly, Hall)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry A.","family":"Rood","sequence":"additional","affiliation":[{"name":"Utah Veterinary Diagnostic Laboratory, Logan, UT (Baldwin, Kelly, Hall)"},{"name":"Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT (Baldwin, Rood, Kelly, Hall)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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