{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T11:00:10Z","timestamp":1781262010307,"version":"3.54.1"},"reference-count":50,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,8,8]],"date-time":"2012-08-08T00:00:00Z","timestamp":1344384000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>A syndrome of progressive right-sided heart failure occurred among yearling Holsteins at a heifer-raising facility and 2 dairies on the Colorado Front Range between 2007 and 2011. Most cases were seen at the heifer-raising facility, where the disease ranked second only to pneumonia as a major cause of death in animals aged &lt;1.5 years. The disease resulted in the death or premature sale of 55 animals over the 5-year period. Affected heifers were 4\u201315 months old when they developed dyspnea, tachycardia, distention and pulsation of jugular veins, lethargy, and weight loss. Clinical progression in most was rapid (2 days to 2 weeks). Ten cattle with typical clinical signs were examined postmortem between 2008 and 2010. Seven developed clinical signs after transportation 57\u2013238 days earlier from Wisconsin (elevation: &lt; 275 m); the remaining 3 animals were born and raised at an altitude of 1,600 m. At necropsy, the 10 cattle had marked hypertrophy of right ventricular myocardium, dilated right atria, right ventricles, and pulmonary trunks, as well as hepatomegaly, ascites, and serous atrophy of fat. The principal histological change in lungs was hypertrophied tunicae adventitia and media of muscular arteries. Hepatic changes were typical of chronic passive congestion. Ultrastructural changes in heart were consistent with uncomplicated hypertrophy of cardiocytes with no evidence of primary cardiomyopathy. The syndrome most likely represents brisket disease due to pulmonary hypertension at the modest elevation of 1,600 m.<\/jats:p>","DOI":"10.1177\/1040638712453580","type":"journal-article","created":{"date-parts":[[2012,8,22]],"date-time":"2012-08-22T17:17:02Z","timestamp":1345655822000},"page":"867-877","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Right ventricular hypertrophy with heart failure in Holstein heifers at elevation of 1,600 meters"],"prefix":"10.1177","volume":"24","author":[{"given":"Christopher R.","family":"Malherbe","sequence":"first","affiliation":[{"name":"Dairy Authority LLC, Greeley, CO (Malherbe)"},{"name":"Wyoming State Veterinary Laboratory, Laramie, WY (Marquard, O\u2019Toole)"},{"name":"Department of Renewable Resources (Legg), University of Wyoming, Laramie, WY"},{"name":"Department of Animal Science (Cammack), University of Wyoming, Laramie, WY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Marquard","sequence":"additional","affiliation":[{"name":"Dairy Authority LLC, Greeley, CO (Malherbe)"},{"name":"Wyoming State Veterinary Laboratory, Laramie, WY (Marquard, O\u2019Toole)"},{"name":"Department of Renewable Resources (Legg), University of Wyoming, Laramie, WY"},{"name":"Department of Animal Science (Cammack), University of Wyoming, Laramie, WY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Legg","sequence":"additional","affiliation":[{"name":"Dairy Authority LLC, Greeley, CO (Malherbe)"},{"name":"Wyoming State Veterinary Laboratory, Laramie, WY (Marquard, O\u2019Toole)"},{"name":"Department of Renewable Resources (Legg), University of Wyoming, Laramie, WY"},{"name":"Department of Animal Science (Cammack), University of Wyoming, Laramie, WY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi M.","family":"Cammack","sequence":"additional","affiliation":[{"name":"Dairy Authority LLC, Greeley, CO (Malherbe)"},{"name":"Wyoming State Veterinary Laboratory, Laramie, WY (Marquard, O\u2019Toole)"},{"name":"Department of Renewable Resources (Legg), University of Wyoming, Laramie, WY"},{"name":"Department of Animal Science (Cammack), University of Wyoming, Laramie, WY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donal","family":"O\u2019Toole","sequence":"additional","affiliation":[{"name":"Dairy Authority LLC, Greeley, CO (Malherbe)"},{"name":"Wyoming State Veterinary Laboratory, Laramie, WY (Marquard, O\u2019Toole)"},{"name":"Department of Renewable Resources (Legg), University of Wyoming, Laramie, WY"},{"name":"Department of Animal Science (Cammack), University of Wyoming, Laramie, WY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,8,8]]},"reference":[{"key":"bibr1-1040638712453580","first-page":"680","volume":"20","author":"Alexander AF","year":"1959","journal-title":"Am J Vet Res"},{"key":"bibr2-1040638712453580","first-page":"1094","volume":"24","author":"Alexander AF","year":"1963","journal-title":"Am J Vet Res"},{"key":"bibr3-1040638712453580","first-page":"1098","volume":"24","author":"Alexander AF","year":"1963","journal-title":"Am J Vet Res"},{"key":"bibr4-1040638712453580","first-page":"1042","volume":"26","author":"Alexander AF","year":"1965","journal-title":"Am J Vet Res"},{"key":"bibr5-1040638712453580","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90348-9"},{"key":"bibr6-1040638712453580","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-143-37494"},{"key":"bibr7-1040638712453580","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1972.222.3.561"},{"key":"bibr8-1040638712453580","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1992.tb00341.x"},{"key":"bibr9-1040638712453580","first-page":"151","volume":"21","author":"Bisgard GE","year":"1977","journal-title":"Adv Vet Sci Comp Med"},{"key":"bibr10-1040638712453580","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9975(08)80092-8"},{"key":"bibr11-1040638712453580","first-page":"269","volume-title":"Theory and practice of histological techniques","author":"Callis GM","year":"2002","edition":"5"},{"key":"bibr12-1040638712453580","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(18)33886-4"},{"key":"bibr13-1040638712453580","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-164-40837"},{"key":"bibr14-1040638712453580","first-page":"97","volume":"29","author":"Epling GP","year":"1968","journal-title":"Am J Vet Res"},{"key":"bibr15-1040638712453580","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra035488"},{"key":"bibr16-1040638712453580","first-page":"700","volume-title":"Clinico-pathologic conference from the School of Veterinary Medicine, University of Pennsylvania","volume":"166","author":"Fellers G","year":"1975"},{"key":"bibr17-1040638712453580","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1965.tb49426.x"},{"key":"bibr18-1040638712453580","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.2001.0494"},{"key":"bibr19-1040638712453580","first-page":"409","volume":"15","author":"Glover GH","year":"1918","journal-title":"J Agric Res"},{"key":"bibr20-1040638712453580","first-page":"543","volume":"19","author":"Grover RF","year":"1962","journal-title":"Med Thorac"},{"key":"bibr21-1040638712453580","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvfa.2007.08.001"},{"key":"bibr22-1040638712453580","first-page":"1549","volume":"189","author":"James LF","year":"1986","journal-title":"J Am Vet Med Assoc"},{"key":"bibr23-1040638712453580","doi-asserted-by":"crossref","first-page":"254","DOI":"10.2460\/ajvr.1983.44.02.254","volume":"44","author":"James LF","year":"1983","journal-title":"Am J Vet Res"},{"key":"bibr24-1040638712453580","first-page":"217","volume":"33","author":"James LF","year":"1991","journal-title":"Vet Hum Toxicol"},{"key":"bibr25-1040638712453580","first-page":"257","volume-title":"Diseases of feedlot cattle","author":"Jensen R","year":"1979","edition":"2"},{"key":"bibr26-1040638712453580","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2460\/javma.1976.169.05.515","volume":"169","author":"Jensen R","year":"1976","journal-title":"J Am Vet Med Assoc"},{"key":"bibr27-1040638712453580","first-page":"139","volume-title":"Theory and practice of histological techniques","author":"Jones ML","year":"2002","edition":"5"},{"key":"bibr28-1040638712453580","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1989.tb13584.x"},{"key":"bibr29-1040638712453580","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104749"},{"key":"bibr30-1040638712453580","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.2004.00652.x"},{"key":"bibr31-1040638712453580","first-page":"49","volume-title":"Pathology of domestic animals","volume":"3","author":"Maxie MG","year":"2007","edition":"5"},{"key":"bibr32-1040638712453580","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1990.tb07705.x"},{"key":"bibr33-1040638712453580","doi-asserted-by":"publisher","DOI":"10.1136\/vr.148.11.341"},{"key":"bibr34-1040638712453580","first-page":"172","volume-title":"Analysis of messy data, volume I: designed experiments","author":"Milliken GA","year":"1992"},{"key":"bibr35-1040638712453580","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1979.46.1.184"},{"key":"bibr36-1040638712453580","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2003.11.002"},{"key":"bibr37-1040638712453580","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2010.09.005"},{"key":"bibr38-1040638712453580","first-page":"1168","volume":"74","author":"Parker WH","year":"1962","journal-title":"Vet Rec"},{"key":"bibr39-1040638712453580","first-page":"58","volume-title":"Rebhun\u2019s diseases of dairy cattle","author":"Peek SF","year":"2008","edition":"2"},{"key":"bibr40-1040638712453580","first-page":"717","volume-title":"Diseases of cattle","author":"Pierson RE","year":"1956"},{"key":"bibr41-1040638712453580","doi-asserted-by":"crossref","first-page":"857","DOI":"10.2460\/javma.1991.198.05.857","volume":"198","author":"Pringle JK","year":"1991","journal-title":"J Am Vet Med Assoc"},{"key":"bibr42-1040638712453580","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01017.2004"},{"key":"bibr43-1040638712453580","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199701093360207"},{"key":"bibr44-1040638712453580","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2007-0270"},{"key":"bibr45-1040638712453580","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.012"},{"key":"bibr46-1040638712453580","first-page":"163","volume-title":"Theory and practice of histological techniques","author":"Totty BA","year":"2002","edition":"5"},{"key":"bibr47-1040638712453580","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/8.6.745"},{"key":"bibr48-1040638712453580","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1979.46.3.517"},{"key":"bibr49-1040638712453580","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1975.38.3.491"},{"key":"bibr50-1040638712453580","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1978.45.3.469"}],"container-title":["Journal of Veterinary Diagnostic Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1040638712453580","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1040638712453580","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1040638712453580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:17:02Z","timestamp":1777681022000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1040638712453580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,8]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1177\/1040638712453580"],"URL":"https:\/\/doi.org\/10.1177\/1040638712453580","relation":{},"ISSN":["1040-6387","1943-4936"],"issn-type":[{"value":"1040-6387","type":"print"},{"value":"1943-4936","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,8]]}}}