{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:36:14Z","timestamp":1777930574317,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>A 12-year-old intact male Miniature Schnauzer dog with chronic diarrhea that was unresponsive to empirical treatment was presented to a referring veterinarian. A laparotomy was performed, and formalin-fixed biopsies of duodenum, jejunum, and colon were sent to Oklahoma Animal Disease Diagnostic Laboratory for evaluation. Histologic examination revealed a severe, diffuse, granulomatous enteritis and colitis with intralesional yeast and hyphal forms. Grocott methenamine silver stains revealed short, aseptate hyphae co-mingled with 2\u20138 \u00b5m, oval to round yeast organisms consistent with Histoplasma capsulatum. The atypical presentation of both yeast and hyphal forms prompted identification of the organism. Direct sequencing of a polymerase chain reaction product from paraffin-embedded intestinal samples confirmed the presence of Ajellomyces capsulatus with a homology over 99% to several sequences in GenBank. Ajellomyces capsulatus is the holomorphic name for H. capsulatum. Therefore, the mycelial form of a dimorphic fungus such as H. capsulatum can coexist with yeast cells within lesions of histoplasmosis. Following diagnosis, the dog was treated with itraconazole for 6 months and has improved.<\/jats:p>","DOI":"10.1177\/1040638713479604","type":"journal-article","created":{"date-parts":[[2013,3,19]],"date-time":"2013-03-19T19:23:06Z","timestamp":1363720986000},"page":"304-307","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Canine intestinal histoplasmosis containing hyphal forms"],"prefix":"10.1177","volume":"25","author":[{"given":"Loni L.","family":"Schumacher","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathobiology, Center for Veterinary Health Sciences (Schumacher, Love, Ritchey)"},{"name":"Department of Animal Science (DeSilva, Fernando), Oklahoma State University, Stillwater, OK"},{"name":"Town and Country Veterinary Clinic, McAlester, OK (Ferrell)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda C.","family":"Love","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, Center for Veterinary Health Sciences (Schumacher, Love, Ritchey)"},{"name":"Department of Animal Science (DeSilva, Fernando), Oklahoma State University, Stillwater, OK"},{"name":"Town and Country Veterinary Clinic, McAlester, OK (Ferrell)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Ferrell","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, Center for Veterinary Health Sciences (Schumacher, Love, Ritchey)"},{"name":"Department of Animal Science (DeSilva, Fernando), Oklahoma State University, Stillwater, OK"},{"name":"Town and Country Veterinary Clinic, McAlester, OK (Ferrell)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udaya","family":"DeSilva","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, Center for Veterinary Health Sciences (Schumacher, Love, Ritchey)"},{"name":"Department of Animal Science (DeSilva, Fernando), Oklahoma State University, Stillwater, OK"},{"name":"Town and Country Veterinary Clinic, McAlester, OK (Ferrell)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruchika","family":"Fernando","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, Center for Veterinary Health Sciences (Schumacher, Love, Ritchey)"},{"name":"Department of Animal Science (DeSilva, Fernando), Oklahoma State University, Stillwater, OK"},{"name":"Town and Country Veterinary Clinic, McAlester, OK (Ferrell)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry W.","family":"Ritchey","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, Center for Veterinary Health Sciences (Schumacher, Love, Ritchey)"},{"name":"Department of Animal Science (DeSilva, Fernando), Oklahoma State University, Stillwater, OK"},{"name":"Town and Country Veterinary Clinic, McAlester, OK (Ferrell)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,3,19]]},"reference":[{"key":"bibr1-1040638713479604","first-page":"614","volume-title":"Infectious diseases of the dog and cat","author":"Br\u00f6mel C","year":"2012","edition":"4"},{"key":"bibr2-1040638713479604","doi-asserted-by":"publisher","DOI":"10.1053\/j.ctsap.2005.07.003"},{"key":"bibr3-1040638713479604","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2009.00120.x"},{"key":"bibr4-1040638713479604","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00027-06"},{"key":"bibr5-1040638713479604","doi-asserted-by":"publisher","DOI":"10.1177\/030098587901600217"},{"key":"bibr6-1040638713479604","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00757-11"},{"key":"bibr7-1040638713479604","doi-asserted-by":"publisher","DOI":"10.2307\/3757791"},{"key":"bibr8-1040638713479604","first-page":"464","volume-title":"Medical mycology","author":"Kwon-Chung KJ","year":"1992","edition":"2"},{"key":"bibr9-1040638713479604","first-page":"32","volume-title":"Medical mycology","author":"Kwon-Chung KJ","year":"1992","edition":"2"},{"key":"bibr10-1040638713479604","first-page":"48","volume-title":"Medically important fungi, a guide to identification","author":"Larone DH","year":"2011","edition":"5"},{"key":"bibr11-1040638713479604","first-page":"157","volume":"8","author":"McGinnis MR","year":"1979","journal-title":"Mycotaxon"},{"key":"bibr12-1040638713479604","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-45.3.692"},{"key":"bibr13-1040638713479604","doi-asserted-by":"publisher","DOI":"10.1378\/chest.25.1.54"},{"key":"bibr14-1040638713479604","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msr121"},{"key":"bibr15-1040638713479604","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1135(03)00104-4"},{"key":"bibr16-1040638713479604","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(03)00080-8"}],"container-title":["Journal of Veterinary Diagnostic Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1040638713479604","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1040638713479604","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1040638713479604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:17:32Z","timestamp":1777681052000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1040638713479604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1177\/1040638713479604"],"URL":"https:\/\/doi.org\/10.1177\/1040638713479604","relation":{},"ISSN":["1040-6387","1943-4936"],"issn-type":[{"value":"1040-6387","type":"print"},{"value":"1943-4936","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}