{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T16:14:10Z","timestamp":1779898450393,"version":"3.53.1"},"reference-count":36,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J VET Diagn Invest"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>A 2.5-year-old intact male miniature lop rabbit ( Oryctolagus cuniculus) was presented with multiple nodules surrounding the eyes, nose, mouth, and prepuce. Cytological evaluation of the periocular nodules revealed the presence of intracellular (within macrophages) and extracellular yeast organisms. The yeast organisms were approximately 3\u20135 \u00b5m in diameter, round to oval, with a thin clear capsule, and contained an eccentrically placed basophilic crescent-shaped nucleus. The clinical pathological interpretation was granulomatous inflammation with intralesional yeast of a morphology consistent with Histoplasma spp. The rabbit was treated with microsized griseofulvin (25 mg\/kg, orally, once a day) for 12 days pending final cytological diagnosis of histoplasmosis. No significant improvement was noted during the treatment period, and humane euthanasia was performed. Postmortem examination revealed the presence of intracellular and extracellular yeast organisms in the small intestine, skin (antebrachium, perioral, palpebral, perianal, and pinnal), penis, penile urethra, rectum, axillary lymph node, and conjunctiva. Postmortem fungal culture yielded Histoplasma capsulatum. Based on clinical and postmortem findings, a definitive diagnosis of disseminated histoplasmosis was made. Disseminated histoplasmosis appears to be unreported in rabbits. Although the treatment used did not provide noticeable improvement, available information on histoplasmosis treatment in other species has been reviewed to provide useful information for future management of this condition in rabbits.<\/jats:p>","DOI":"10.1177\/1040638713516623","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T00:10:44Z","timestamp":1390435844000},"page":"158-162","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Disseminated histoplasmosis (\n                    <i>Histoplasma capsulatum<\/i>\n                    ) in a pet rabbit: case report and review of the literature"],"prefix":"10.1177","volume":"26","author":[{"given":"Jo\u00e3o","family":"Brand\u00e3o","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences (Brand\u00e3o, Woods, Pucheu-Haston, Johnson, Tully), School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"},{"name":"Louisiana Animal Disease Diagnostic Laboratory (Fowlkes, Leissinger, Blair), School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"},{"name":"Kees Park Animal Clinic, Pineville, LA (Elster Phillips)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Woods","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences (Brand\u00e3o, Woods, Pucheu-Haston, Johnson, Tully), School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"},{"name":"Louisiana Animal Disease Diagnostic Laboratory (Fowlkes, Leissinger, Blair), School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"},{"name":"Kees Park Animal Clinic, Pineville, LA (Elster Phillips)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Fowlkes","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences (Brand\u00e3o, Woods, Pucheu-Haston, Johnson, Tully), School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"},{"name":"Louisiana Animal Disease Diagnostic Laboratory (Fowlkes, Leissinger, Blair), School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"},{"name":"Kees Park Animal Clinic, Pineville, LA (Elster Phillips)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Leissinger","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences (Brand\u00e3o, Woods, Pucheu-Haston, Johnson, Tully), School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"},{"name":"Louisiana Animal Disease Diagnostic Laboratory (Fowlkes, Leissinger, Blair), School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"},{"name":"Kees Park Animal Clinic, Pineville, LA (Elster Phillips)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Blair","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences (Brand\u00e3o, Woods, Pucheu-Haston, Johnson, Tully), School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"},{"name":"Louisiana Animal Disease Diagnostic Laboratory (Fowlkes, Leissinger, Blair), School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"},{"name":"Kees Park Animal Clinic, Pineville, LA (Elster Phillips)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cherie","family":"Pucheu-Haston","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences (Brand\u00e3o, Woods, Pucheu-Haston, Johnson, Tully), School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"},{"name":"Louisiana Animal Disease Diagnostic Laboratory (Fowlkes, Leissinger, Blair), School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"},{"name":"Kees Park Animal Clinic, Pineville, LA (Elster Phillips)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences (Brand\u00e3o, Woods, Pucheu-Haston, Johnson, Tully), School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"},{"name":"Louisiana Animal Disease Diagnostic Laboratory (Fowlkes, Leissinger, Blair), School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"},{"name":"Kees Park Animal Clinic, Pineville, LA (Elster Phillips)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Elster Phillips","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences (Brand\u00e3o, Woods, Pucheu-Haston, Johnson, Tully), School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"},{"name":"Louisiana Animal Disease Diagnostic Laboratory (Fowlkes, Leissinger, Blair), School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"},{"name":"Kees Park Animal Clinic, Pineville, LA (Elster Phillips)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Tully","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences (Brand\u00e3o, Woods, Pucheu-Haston, Johnson, Tully), School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"},{"name":"Louisiana Animal Disease Diagnostic Laboratory (Fowlkes, Leissinger, Blair), School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"},{"name":"Kees Park Animal Clinic, Pineville, LA (Elster Phillips)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,1,22]]},"reference":[{"key":"bibr1-1040638713516623","doi-asserted-by":"publisher","DOI":"10.2307\/4592099"},{"key":"bibr2-1040638713516623","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-5758"},{"key":"bibr3-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/22.Supplement_2.S102"},{"key":"bibr4-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-011-9477-8"},{"key":"bibr5-1040638713516623","first-page":"614","volume-title":"Infectious diseases of the dog and cat","author":"Br\u00f6mel C","year":"2012","edition":"4"},{"key":"bibr6-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1128\/JB.96.5.1535-1539.1968"},{"key":"bibr7-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1086\/313748"},{"key":"bibr8-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1960.03730050056010"},{"key":"bibr9-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(89)90044-3"},{"key":"bibr10-1040638713516623","first-page":"579","volume-title":"In: Infectious diseases of the dog and cat","author":"Greene CE","year":"2012","edition":"4"},{"key":"bibr11-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1590\/S1517-83822006000100001"},{"key":"bibr12-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1950.91"},{"key":"bibr13-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1994.tb03260.x"},{"key":"bibr14-1040638713516623","doi-asserted-by":"publisher","DOI":"10.7589\/0090-3558-17.2.191"},{"key":"bibr15-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.32.2.209"},{"key":"bibr16-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1080\/02681218680000051"},{"key":"bibr17-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00027-06"},{"key":"bibr18-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(03)00035-4"},{"key":"bibr19-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1159\/000219535"},{"key":"bibr20-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1086\/523576"},{"key":"bibr21-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2004.tb00057.x"},{"key":"bibr22-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.11.2307"},{"key":"bibr23-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.12.2681"},{"key":"bibr24-1040638713516623","first-page":"52","volume":"71","author":"Pillsbury DM","year":"1959","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"bibr25-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1080\/03079457.2011.554796"},{"key":"bibr26-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1086\/342384"},{"key":"bibr27-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(73)90494-7"},{"key":"bibr28-1040638713516623","doi-asserted-by":"publisher","DOI":"10.2460\/javma.232.1.74"},{"key":"bibr29-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.6.1512-1517.2000"},{"key":"bibr30-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.7.2343-2345.1999"},{"key":"bibr31-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2006.01253.x"},{"key":"bibr32-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1086\/323781"},{"key":"bibr33-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1086\/521259"},{"key":"bibr34-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1006\/fgbi.2001.1311"},{"key":"bibr35-1040638713516623","doi-asserted-by":"publisher","DOI":"10.1177\/104063879500700430"},{"key":"bibr36-1040638713516623","first-page":"376","volume":"52","author":"Zia SA","year":"2002","journal-title":"J Pak Med Assoc"}],"container-title":["Journal of Veterinary Diagnostic Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1040638713516623","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1040638713516623","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1040638713516623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:18:03Z","timestamp":1777681083000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1040638713516623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1177\/1040638713516623"],"URL":"https:\/\/doi.org\/10.1177\/1040638713516623","relation":{},"ISSN":["1040-6387","1943-4936"],"issn-type":[{"value":"1040-6387","type":"print"},{"value":"1943-4936","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}